Traumatic bleeding and mortality in mice are intensified by iron deficiency anemia and can be rescued with tranexamic acid
These observations provide first and critical proof-of-principle evidence that anemia accelerates traumatic bleeding and increases mortality, which could be rescued by anemia correction (parenteral iron) or periprocedural TXA.
Authors
- Tro Sekayan (ORCID: https://orcid.org/0009-0009-7050-0020)
- Annette von Drygalski (ORCID: https://orcid.org/0000-0002-9426-6322)
- Veronica H. Flood (ORCID: https://orcid.org/0000-0001-8998-6838)
- Bilgimol Chumappumkal Joseph (ORCID: https://orcid.org/0000-0003-2756-4546)
- R. F. W. Barnes (ORCID: https://orcid.org/0000-0002-2721-4151)
- Juan A De Pablo-Moreno
- Nicca Falah
Institutions
- Universidad Complutense de Madrid (ES)
- University of California San Diego (US)
- Versiti Blood Center of Wisconsin (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.rpth.2024.102543
- Citations
- 3
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- University of California, San Diego