Oocyte‐specific deletion of eukaryotic translation initiation factor 5 causes apoptosis of mouse oocytes within the early‐growing follicles by mitochondrial fission defect‐reactive oxygen species‐DNA damage
Eif5 deletion in oocytes leads to arrest in oocyte growth and follicle development. Eif5 deletion in oocytes impairs the translation of mitochondrial fission-related proteins, followed by mitochondrial dysfunction. Depletion of Eif5 causes oocyte apoptosis via ROS accumulation and DNA damage response pathway.
Authors
- Tiantian Hao
- Hongwei Wei
- Xiaoqiong Hao
- Weiyong Wang (ORCID: https://orcid.org/0000-0002-8607-3379)
- Shuang Liu (ORCID: https://orcid.org/0000-0003-3301-6925)
- Meijia Zhang (ORCID: https://orcid.org/0000-0001-7803-3054)
- Wenjun Zhou (ORCID: https://orcid.org/0009-0009-1865-7514)
- Ying Wei
- Huiyu Liu (ORCID: https://orcid.org/0000-0003-4465-8501)
- Xiaodan Zhang (ORCID: https://orcid.org/0000-0001-5248-4287)
Institutions
- Baotou Medical College (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1791
- Citations
- 11
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia
- National Key Research and Development Program of China