Single‐cell transcriptome analysis deciphers the CD74‐mediated immune evasion and tumour growth in lung squamous cell carcinoma with chronic obstructive pulmonary disease
Our results demonstrated higher proportions of tumour-associated macrophages (TAMs) and higher levels of exhaustion molecules in CD8<sup>+</sup> T cells in the microenvironment of LSCC with COPD. CD74<sup>+</sup>tumour cells were associated with poor disease prognosis. Migration inhibitory factor (MIF)-CD74 may interact with CD8<sup>+</sup> T cells and impair their anti-tumour activity by regulating the PI3K-STAT3-PD-L1 signalling pathway, facilitating immune evasion.
Authors
- Wengeng Zhang (ORCID: https://orcid.org/0000-0002-1000-4692)
- Denian Wang (ORCID: https://orcid.org/0000-0002-0748-7267)
- Kang Xie (ORCID: https://orcid.org/0000-0001-8832-3215)
- Guiyi Ji
- Bojiang Chen (ORCID: https://orcid.org/0000-0002-4882-9817)
- Sixiang Li
- Jian Yang (ORCID: https://orcid.org/0000-0002-3390-5127)
- Yan Wang (ORCID: https://orcid.org/0000-0002-4006-5859)
- Dan Liu
- Weimin Li (ORCID: https://orcid.org/0000-0003-0985-0311)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-7888-8204)
- Chunyan Yu (ORCID: https://orcid.org/0000-0002-9260-6629)
- Kaige Wang (ORCID: https://orcid.org/0000-0001-5407-0395)
- Hongchun Li (ORCID: https://orcid.org/0000-0002-3446-2962)
- Ying Yang
- Qingyan Li (ORCID: https://orcid.org/0000-0002-3840-6976)
- Daxing Zhu (ORCID: https://orcid.org/0000-0002-1325-7847)
- Zhi Yang
- Peng-Fei Wu
- Yanyan Liu (ORCID: https://orcid.org/0000-0002-2821-9253)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1786
- Citations
- 17
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 4.09
Funders
- National Natural Science Foundation of China