Loss of <i>STK11</i> Suppresses Lipid Metabolism and Attenuates <i>KRAS</i> -Induced Immunogenicity in Patients with Non–Small Cell Lung Cancer
In patients with lung cancer, we demonstrate that KRAS mutations increase tumor immunogenicity; however, KRAS/STK11 co-mutated patients display an immune-excluded phenotype. KRAS/STK11 co-mutated patients also demonstrated significant downregulation of several key lipid metabolism genes, many of which were associated with increased immunogenicity and improved overall survival in KRAS-mutated patients. Hence, alteration to lipid metabolism warrants further study as a potential biomarker and target for therapy in patients with KRAS-mutated lung cancer.
Authors
- Hidayatullah G. Munshi (ORCID: https://orcid.org/0000-0002-9552-0775)
- Ryan Huu-Tuan Nguyen (ORCID: https://orcid.org/0000-0002-8863-6649)
- Alexandre F. Aissa (ORCID: https://orcid.org/0000-0002-0759-4011)
- Mary Pasquinelli (ORCID: https://orcid.org/0000-0002-1015-1908)
- Daniel R. Principe (ORCID: https://orcid.org/0000-0003-4355-6597)
- Frank Weinberg (ORCID: https://orcid.org/0000-0002-0094-3725)
- Alicia Hulbert (ORCID: https://orcid.org/0000-0002-1196-1953)
Institutions
- Northwestern University (US)
- University of Wisconsin–Madison (US)
- University of Illinois Chicago (US)
- Indo-American Center (US)
- Jesse Brown VA Medical Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0153
- Citations
- 7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- Northwestern University
- National Institutes of Health
- University of Illinois at Urbana-Champaign
- Robert H. Lurie Comprehensive Cancer Center
- Cancer Center, University of Illinois at Chicago