Ophthalmic Tethered Gold Yarnball‐Mediated Retained Drug Delivery for Eye Fundus Disease Treatment
Drug Delivery In article number 2400095, Yueh Chien, Shang-Hsiu Hu, Shih-Hwa Chiou, and co-workers developed an in situ ophthalmic tethered gold yarnball (GY) that doubles as an ocular retention agent and quercetin (QC) reservoir to overcome low fundus drug retention. After intravitreal injection, QC@GYs enhanced retinal cell leakage and internal limiting membrane permeability, facilitating the partial penetration of QC@GYs into the intra-retinal tissue.
Authors
- Yueh Chien (ORCID: https://orcid.org/0000-0002-1528-9252)
- Shih‐Jen Chen (ORCID: https://orcid.org/0000-0001-9798-1578)
- Henkie Isahwan Ahmad Mulyadi Lai (ORCID: https://orcid.org/0000-0001-8516-743X)
- De‐Kuang Hwang (ORCID: https://orcid.org/0000-0001-6346-8485)
- Shang‐Hsiu Hu (ORCID: https://orcid.org/0000-0002-8965-3918)
- Tai‐Chi Lin (ORCID: https://orcid.org/0000-0003-1163-0457)
- Guang‐Yuh Chiou (ORCID: https://orcid.org/0000-0003-1302-5664)
- Shih‐Hwa Chiou (ORCID: https://orcid.org/0000-0002-8651-5755)
- Yi‐Ying Lin
- Min‐Ren Chiang
- Shih‐Jie Chou
- You‐Ren Wu (ORCID: https://orcid.org/0009-0009-3817-8190)
- Aliaksandr A. Yarmishyn
- Chih‐Ying Chen (ORCID: https://orcid.org/0009-0004-9199-5652)
- I‐Chieh Wang
- Yi‐Ping Yang (ORCID: https://orcid.org/0000-0002-4629-5647)
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Tsing Hua University (TW)
- Taipei Veterans General Hospital (TW)
- Genomics Research Center, Academia Sinica (TW)
- IMU University (MY)
Publication Details
- Journal
- Small Science
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/smsc.202470031
- Primary Topic
- Retinal and Optic Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00