TRAbectedin in adVanced rEtroperitoneal well differentiated/dedifferentiated Liposarcoma and Leiomyosarcoma (TRAVELL): results of a phase II study from the Italian Sarcoma Group
While the primary endpoint of the study was not met, we noticed a subgroup of patients with a markedly discrepant TTP with trabectedin in comparison to previous therapy (GMI <0.5 or >2, the latter including some patients with a long TTP with trabectedin). A mismatch between PFS and overall survival was observed, possibly due to the natural history of the two different histologies and the availability of further lines in LMS.
Authors
- Alfredo Berruti (ORCID: https://orcid.org/0000-0002-3956-0043)
- Alessandro Mazzocca
- Chiara Fabbroni (ORCID: https://orcid.org/0000-0002-9818-528X)
- Angelo Paolo Dei Tos (ORCID: https://orcid.org/0000-0002-1228-8940)
- Andrea Marrari (ORCID: https://orcid.org/0000-0001-6363-9299)
- Paolo G. Casali (ORCID: https://orcid.org/0000-0003-4056-8023)
- Sonia Fatigoni (ORCID: https://orcid.org/0000-0002-0106-2268)
- Maria Abbondanza Pantaleo (ORCID: https://orcid.org/0000-0002-0177-6957)
- Monica Giordano (ORCID: https://orcid.org/0000-0002-8652-3907)
- Annalisa Alberton
- Antonella Boglione
- Tommaso Martino De Pas
- Giovanni Grignani (ORCID: https://orcid.org/0000-0001-5515-569X)
- Eliana Rulli (ORCID: https://orcid.org/0000-0003-1058-4137)
- Elena Fumagalli (ORCID: https://orcid.org/0000-0003-4814-7637)
- Roberta Sanfilippo (ORCID: https://orcid.org/0000-0002-9704-0521)
- Luciano Carlucci (ORCID: https://orcid.org/0000-0002-1008-5066)
- Giacomo Giulio Baldi (ORCID: https://orcid.org/0000-0003-0798-7752)
- Bruno Vincenzi (ORCID: https://orcid.org/0000-0001-8222-9025)
- S. Aliberti (ORCID: https://orcid.org/0000-0001-6990-9341)
- Antonella Brunello (ORCID: https://orcid.org/0000-0003-2583-5226)
Institutions
- University of Padua (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Surgical Specialties (Canada) (CA)
- Istituto Oncologico Veneto (IT)
- Ospedale Humanitas Gradenigo (IT)
- Azienda USL di Bologna (IT)
- Azienda Ospedaliera S.Maria (IT)
- Humanitas Gavazzeni (IT)
- Azienda Socio Sanitaria Territoriale Lariana (IT)
- Campus Bio Medico University Hospital (IT)
- Candiolo Cancer Institute (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- IRCCS Humanitas Research Hospital (IT)
- Hospital of Prato (IT)
- European Institute of Oncology (IT)
- University of Brescia (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.esmoop.2024.103667
- Citations
- 5
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.09