Kidney Blood Flow and Renin-Angiotensin-Aldosterone System Measurements Associated With Kidney and Cardiovascular Dysfunction in Pediatric Shock
In pediatric shock, kidney blood flow was abnormal and renin and aldosterone were elevated in those with AKI. Kidney blood flow abnormalities are independently associated with future cardiovascular dysfunction; renin elevations are independently associated with future kidney dysfunction. Kidney blood flow by POCUS may identify children who will have persistent as opposed to resolving AKI. RAAS perturbations may drive AKI in pediatric shock.
Authors
- Fiore Mastroianni (ORCID: https://orcid.org/0000-0002-1434-4424)
- Kristina Murphy (ORCID: https://orcid.org/0000-0002-1128-4876)
- Daniel E. Leisman (ORCID: https://orcid.org/0000-0001-9670-9425)
- Grace Fisler (ORCID: https://orcid.org/0000-0001-7001-000X)
- Clifford S. Deutschman (ORCID: https://orcid.org/0000-0001-9490-4024)
- Matthew Taylor (ORCID: https://orcid.org/0000-0003-2643-3050)
- James B. Schneider
Institutions
- Northwell Health (US)
- Beth Israel Deaconess Medical Center (US)
- Feinstein Institute for Medical Research (US)
- Long Island University (US)
- Massachusetts General Hospital (US)
- Cohen Children's Medical Center (US)
- New York University (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1097/cce.0000000000001134
- Citations
- 2
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- La Jolla Pharmaceutical Company
- Northwell Health
- National Institutes of Health
- Feinstein Institutes for Medical Research