A Novel Drug Candidate for Sepsis Targeting Heparanase by Inhibiting Cytokine Storm (Adv. Sci. 29/2024)
Novel Drug Candidate for Sepsis Sepsis currently has no specific clinical treatment. The main cause of multi‐organ failure and death in sepsis is increased vascular permeability due to endothelial damage. Hongzhen Jin, Wei Zhao, Fan Yu, and co‐workers have developed a drug targeting Heparanase through screening. The drug significantly protects the vascular endothelial glycocalyx and improves survival rates in sepsis mouse models from 0 to 80%, making it a promising candidate for sepsis. More details can be found in article number 2403337. [Image: see text]
Authors
- Manli Wang (ORCID: https://orcid.org/0000-0001-8701-3530)
- Peng George Wang (ORCID: https://orcid.org/0000-0003-3335-6794)
- Tiehai Li (ORCID: https://orcid.org/0000-0002-3600-1828)
- Song Yang (ORCID: https://orcid.org/0000-0003-1840-8429)
- Peng Gong (ORCID: https://orcid.org/0000-0002-1100-7393)
- Fan Yu (ORCID: https://orcid.org/0000-0003-1562-250X)
- Guoqiang Zhang (ORCID: https://orcid.org/0000-0003-1728-3847)
- Mingyang Liu (ORCID: https://orcid.org/0000-0003-4101-716X)
- Yonghui Liu
- Danyang Wang (ORCID: https://orcid.org/0000-0003-2499-1972)
- Xianwei Ding
- Ke Feng (ORCID: https://orcid.org/0000-0003-4476-1939)
- Haomiao Zhu (ORCID: https://orcid.org/0000-0003-0045-9033)
- Hongzhen Jin
- Kaixuan Wang (ORCID: https://orcid.org/0009-0006-2221-8256)
- Wei Guang Zhao (ORCID: https://orcid.org/0000-0002-7887-2357)
- Qiutong Liu
- Kun Wang (ORCID: https://orcid.org/0009-0005-4052-6909)
Publication Details
- Journal
- Advanced Science
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/advs.202470175
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.24