Targeting tumor-associated macrophage-derived CD74 improves efficacy of neoadjuvant chemotherapy in combination with PD-1 blockade for cervical cancer
Our study reveals the dynamic cell-cell interaction network in the cervical cancer microenvironment influenced by combining NACT and PD-1 blockade. Furthermore, blocking tumor-associated macrophage-derived CD74 could augment neoadjuvant therapeutic efficacy.
Authors
- Qing Zhang (ORCID: https://orcid.org/0009-0007-8022-1688)
- Jinwen Ye (ORCID: https://orcid.org/0000-0002-0409-250X)
- Zixiang Wang (ORCID: https://orcid.org/0000-0001-5252-9764)
- Baoxia Cui (ORCID: https://orcid.org/0009-0002-1721-4155)
- Zhonghao Mao
- Youzhong Zhang (ORCID: https://orcid.org/0000-0002-6132-141X)
- Xinlin Jiao
- Teng Zhang (ORCID: https://orcid.org/0000-0002-5310-8766)
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-5344-2625)
- Feng Yuan (ORCID: https://orcid.org/0000-0002-6981-8324)
- Bingyu Wang (ORCID: https://orcid.org/0000-0002-2288-7584)
- Meining Xu
Institutions
- Shandong University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/jitc-2024-009024
- Citations
- 24
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 5.77
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China