A novel peptide encoded by circ‐SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac‐mediated CD36 transcription in NAFLD
Under normal circumstances, driven by m6A modification, YTHDF2 directly recognizes and degrades circ-SLC9A6, thereby inhibiting the translation of SLC9A6-126aa. Additionally, AKT1 phosphorylates and inhibits the nuclear translocation of SLC9A6-126aa. In NAFLD, lipid overload leads to YTHDF2 and AKT1 deficiency, ultimately increasing the expression and nuclear import of SLC9A6-126aa. Nuclear SLC9A6-126aa binds directly to the CD36 promoter and initiates CD36 transcription, which induces lipid dyshomeostasis.
Authors
- Jihong Yao (ORCID: https://orcid.org/0000-0001-5940-9167)
- Xinyao Tian
- Deshun Liu (ORCID: https://orcid.org/0009-0008-6318-9820)
- Zuoyu Tu
- Xuzi Zhao
- Zekuan Li
- Yue Wang (ORCID: https://orcid.org/0000-0001-6936-5081)
- Shusen Zheng (ORCID: https://orcid.org/0000-0003-1459-8261)
- Yan Zhao (ORCID: https://orcid.org/0009-0008-1051-7237)
- Zhecheng Wang (ORCID: https://orcid.org/0000-0002-2128-3834)
- Xin Sun (ORCID: https://orcid.org/0000-0001-7035-593X)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Zero to Three (US)
- Hangzhou Red Cross Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1801
- Citations
- 15
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- National Natural Science Foundation of China