The <scp>mGluR5</scp>‐mediated Arc activation protects against experimental traumatic brain injury in rats
In summary, the present data indicate that the mGluR5-mediated Arc activation is a protective mechanism that attenuates neurotoxicity following TBI through the regulation of intracellular Ca<sup>2+</sup> hemostasis. The AMPAR-associated Ca<sup>2+</sup> influx and ER Ca<sup>2+</sup> release induced by Homer1-IP<sub>3</sub>R pathway might be involved in this protection.
Authors
- Xu Ren
- Tao Chen (ORCID: https://orcid.org/0000-0001-9148-7704)
- Yunfei Li (ORCID: https://orcid.org/0000-0002-8413-0026)
- Yu‐Hai Wang (ORCID: https://orcid.org/0000-0002-1752-0315)
Institutions
- Anhui Medical University (CN)
- Wuxi Taihu Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/cns.14695
- Citations
- 6
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province