<scp>S100A9</scp> deletion in microglia/macrophages ameliorates brain injury through the <scp>STAT6</scp>/<scp>PPARγ</scp> pathway in ischemic stroke
This study provides evidence for the first time that S100A9 in classical monocytes could potentially be a biomarker for predicting IS prognosis and reveals a novel therapeutic strategy for IS. By demonstrating that S100A9-mediated M/M polarization and phagocytosis can be reversed by S100A9 inhibition in a STAT6/PPARγ pathway-dependent manner, this study opens up new avenues for drug development in the field.
Authors
- Jianbo Gao (ORCID: https://orcid.org/0000-0003-2621-3701)
- Man Jiang (ORCID: https://orcid.org/0000-0002-0470-8722)
- Ting Zhao (ORCID: https://orcid.org/0000-0003-3502-6043)
- Jian Jun Jin (ORCID: https://orcid.org/0000-0002-2387-3862)
- Qiongqiong Hu
- Jian Wang (ORCID: https://orcid.org/0000-0003-2291-640X)
- Xi Liu (ORCID: https://orcid.org/0000-0003-3592-381X)
- Junmin Wang (ORCID: https://orcid.org/0000-0001-9830-0164)
Institutions
- Zhengzhou University (CN)
- Zhengzhou Central Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Zhengzhou People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/cns.14881
- Citations
- 24
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 5.61