Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity—IVY Network, 26 Hospitals, 18 October 2023–9 March 2024
Updated 2023-2024 COVID-19 vaccination provided protection against both XBB and JN lineage hospitalization, but protection against the latter may be attenuated by immune escape. Clinical severity of JN lineage hospitalizations was not higher relative to XBB.
Authors
- Jarrod Mosier (ORCID: https://orcid.org/0000-0002-5371-0845)
- Christopher Mallow (ORCID: https://orcid.org/0000-0002-8211-7629)
- Aleda M. Leis (ORCID: https://orcid.org/0000-0003-2867-9062)
- Sydney A. Swan
- Robert Gottlieb (ORCID: https://orcid.org/0000-0001-8376-8709)
- Adrienne Baughman
- Emily T. Martin (ORCID: https://orcid.org/0000-0002-5771-8895)
- Vasisht Srinivasan (ORCID: https://orcid.org/0000-0001-7954-9730)
- Fatimah S. Dawood (ORCID: https://orcid.org/0000-0002-6609-376X)
- Ithan D. Peltan (ORCID: https://orcid.org/0000-0003-1730-234X)
- Matthew E. Prekker (ORCID: https://orcid.org/0000-0002-3969-3022)
- Abhijit Duggal (ORCID: https://orcid.org/0000-0003-4220-2359)
- Jay S. Steingrub (ORCID: https://orcid.org/0000-0002-6019-6725)
- Jin H. Han (ORCID: https://orcid.org/0000-0003-0384-210X)
- Natalie J. Thornburg (ORCID: https://orcid.org/0000-0003-3523-3616)
- Jamie Felzer (ORCID: https://orcid.org/0000-0002-9317-950X)
- Natasha Halasa (ORCID: https://orcid.org/0000-0002-6381-1826)
- Adit A. Ginde (ORCID: https://orcid.org/0000-0003-2325-206X)
- Jillian P. Rhoads
- Ivana A. Vaughn (ORCID: https://orcid.org/0000-0002-7201-0289)
- Mayur Ramesh (ORCID: https://orcid.org/0000-0002-1677-3994)
- Wesley H. Self (ORCID: https://orcid.org/0000-0002-9300-3045)
- Cassandra A. Johnson
- Nathan Ivan Shapiro (ORCID: https://orcid.org/0000-0003-3508-4390)
- Jonathan D. Casey (ORCID: https://orcid.org/0000-0002-0977-290X)
- Kevin W. Gibbs (ORCID: https://orcid.org/0000-0002-5272-2289)
- Jennifer G. Wilson (ORCID: https://orcid.org/0000-0002-4254-8475)
- David N. Hager (ORCID: https://orcid.org/0000-0002-5148-4872)
- Adam S. Lauring (ORCID: https://orcid.org/0000-0003-2906-8335)
- Sascha Ellington (ORCID: https://orcid.org/0000-0002-5584-5006)
- Nicholas J. Johnson (ORCID: https://orcid.org/0000-0001-9915-0591)
- Todd W. Rice (ORCID: https://orcid.org/0000-0002-7136-5408)
- Lydia J. Atherton (ORCID: https://orcid.org/0009-0005-5038-7092)
- Catherine L. Hough (ORCID: https://orcid.org/0000-0001-6425-0867)
- Safa Saeed
- Steven Y. Chang (ORCID: https://orcid.org/0000-0002-7365-5265)
- Nicholas M. Mohr (ORCID: https://orcid.org/0000-0003-0497-5828)
- Michelle N. Gong (ORCID: https://orcid.org/0000-0001-7952-5384)
- Jennie H. Kwon (ORCID: https://orcid.org/0000-0002-7824-6276)
- Shekhar Ghamande (ORCID: https://orcid.org/0000-0001-6924-9494)
- Akram Khan (ORCID: https://orcid.org/0000-0003-3091-632X)
- Kelsey N. Womack (ORCID: https://orcid.org/0000-0002-4628-8615)
- Basmah Safdar (ORCID: https://orcid.org/0000-0002-9640-7133)
- Nathaniel M. Lewis (ORCID: https://orcid.org/0000-0001-7088-9640)
- Bijal A. Parikh (ORCID: https://orcid.org/0000-0003-2490-8294)
- Samuel M. Brown (ORCID: https://orcid.org/0000-0003-1206-6261)
- Diya Surie (ORCID: https://orcid.org/0000-0003-3931-1423)
- Clinton R. Paden (ORCID: https://orcid.org/0000-0001-8701-8948)
- Jennifer DeCuir
- Yuwei Zhu (ORCID: https://orcid.org/0000-0001-9849-1634)
- Manjusha Gaglani (ORCID: https://orcid.org/0000-0002-3952-9230)
- C. Kevin (ORCID: https://orcid.org/0000-0002-4326-2911)
- Paul W. Blair (ORCID: https://orcid.org/0000-0002-3817-5987)
- Matthew C. Exline (ORCID: https://orcid.org/0000-0001-6797-158X)
- James D. Chappell (ORCID: https://orcid.org/0000-0002-7382-7864)
- Carlos Gabriel Grijalva (ORCID: https://orcid.org/0000-0002-2329-7797)
- Nida Qadir (ORCID: https://orcid.org/0000-0001-7791-049X)
- Leigh Papalambros
- Amira Mohamed (ORCID: https://orcid.org/0009-0002-8381-1265)
- Estelle S. Harris
- Christie Columbus
Institutions
- University of Iowa (US)
- Mount Sinai Beth Israel (US)
- Centers for Disease Control and Prevention (US)
- Albert Einstein College of Medicine (US)
- Cleveland Clinic (US)
- Montefiore Medical Center (US)
- Baystate Medical Center (US)
- University of Arizona (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Emory University (US)
- Henry Ford Health System (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- National Center for Immunization and Respiratory Diseases (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Beth Israel Deaconess Hospital (US)
- Hennepin County Medical Center (US)
- Intermountain Medical Center (US)
- Yale University (US)
- Baylor Scott & White Medical Center - Temple (US)
- Baylor Scott & White Health (US)
- Wake Forest University (US)
- The Ohio State University (US)
- Vanderbilt University Medical Center (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1093/cid/ciae405
- Citations
- 40
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 15.56
Funders
- Centers for Disease Control and Prevention