Cathepsin B-Activatable Bioactive Peptide Nanocarrier for High-Efficiency Immunotherapy of Asthma
Our research demonstrates that MPP-Trp has immunomodulatory effects on Th1/Th2 cell populations, essential in managing asthma. It considerably alleviates OVA-induced asthma by shifting the immune response towards a Th1-dominant profile, thereby reducing Th2-driven inflammation. Therefore, this novel bioactive peptide nanocarrier, MPP-Trp, holds promise as a candidate for asthma immunotherapy.
Authors
- Taiyu Song (ORCID: https://orcid.org/0000-0003-3924-8452)
- Yue Zhao (ORCID: https://orcid.org/0000-0002-6790-3402)
- Lulu Yao
- Qian Zhao (ORCID: https://orcid.org/0000-0002-5340-7475)
- Beibei Zhu (ORCID: https://orcid.org/0000-0002-1134-7574)
- Jinya Wang
- Liu Guang-ling
- Angang Zhu
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/ijn.s455633
- Citations
- 5
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Science Foundation
- National Natural Science Foundation of China