A Case of Pernicious Anemia with Concurrent Beta-Thalassemia Minor

Vitamin B<sub>12</sub> is essential for various bodily functions, and its deficiency may cause hematological manifestations. We report a case of a previously healthy 65-year-old female who was admitted to our hospital with reduced sense of taste and painful tongue. The serum level of vitamin B<sub>12</sub> was decreased. However, her complete blood count did not show any evidence of macrocytosis, instead, her mean corpuscular volume was low. Gene sequencing indicated an β-thalassemia minor and that probably masked the megaloblastic features of vitamin B<sub>12</sub> deficiency.

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Publication Details

Journal
Journal of Blood Medicine
Published
2024-08-01
DOI
https://doi.org/10.2147/jbm.s473075
Primary Topic
Blood groups and transfusion
Type
article
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article

A Case of Pernicious Anemia with Concurrent Beta-Thalassemia Minor

Fuzhen Yuan, Zhenhua Huang, Junsheng Sun, Dingye Yao
Journal of Blood Medicine
Blood groups and transfusion
article

A Case of Pernicious Anemia with Concurrent Beta-Thalassemia Minor

Fuzhen Yuan, Zhenhua Huang, Junsheng Sun, Dingye Yao
article en

Abstract

Vitamin B<sub>12</sub> is essential for various bodily functions, and its deficiency may cause hematological manifestations. We report a case of a previously healthy 65-year-old female who was admitted to our hospital with reduced sense of taste and painful tongue. The serum level of vitamin B<sub>12</sub> was decreased. However, her complete blood count did not show any evidence of macrocytosis, instead, her mean corpuscular volume was low. Gene sequencing indicated an β-thalassemia minor and that probably masked the megaloblastic features of vitamin B<sub>12</sub> deficiency.

Journal of Blood MedicineVol. Volume 15
Guangzhou University of Chinese Medicine (CN), Longgang Central Hospital (CN)
Openalex Percentile: Top 81%
Blood groups and transfusion
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A Case of Pernicious Anemia with Concurrent Beta-Thalassemia Minor — Fuzhen Yuan, Zhenhua Huang, et al. · Journal of Blood Medicine (2024) | TGRS Research Map | TGRS