EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responses
Building on the proven safety profile of EphA3 antibodies in clinical settings, our study provides compelling preclinical evidence supporting the efficacy of EphA3-targeted CAR T cells against high-grade gliomas. These findings underscore the potential for transitioning this innovative therapy into clinical trials, aiming to revolutionize the treatment landscape for patients afflicted with these formidable brain cancers.
Authors
- Raelene Endersby (ORCID: https://orcid.org/0000-0003-3554-2769)
- Melinda Iliopoulos (ORCID: https://orcid.org/0000-0002-7229-4189)
- Ryan Cross (ORCID: https://orcid.org/0000-0002-8573-8551)
- Jordan R. Hansford (ORCID: https://orcid.org/0000-0001-7733-383X)
- Alexander J. Davenport (ORCID: https://orcid.org/0000-0001-9111-4350)
- Katharine J. Drummond (ORCID: https://orcid.org/0000-0002-8152-2120)
- Misty R. Jenkins (ORCID: https://orcid.org/0000-0001-6564-2715)
- Stacie Shiqi Wang (ORCID: https://orcid.org/0000-0001-5476-9323)
- Lisa M. Ebert (ORCID: https://orcid.org/0000-0002-8041-9666)
- Leesa Lertsumitkul (ORCID: https://orcid.org/0000-0002-5328-4399)
- Sarah J McArthur
Institutions
- Royal Adelaide Hospital (AU)
- The Royal Melbourne Hospital (AU)
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- The Kids Research Institute Australia (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- La Trobe University (AU)
- Women's and Children's Hospital (AU)
- South Australian Health and Medical Research Institute (AU)
- Centre for Cancer Biology (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/jitc-2024-009486
- Citations
- 19
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 5.37
Funders
- Cure Brain Cancer Foundation
- Robert Connor Dawes Foundation
- Isabella and Marcus Foundation
- Walter and Eliza Hall Institute of Medical Research
- National Health and Medical Research Council