Heterologous Prime-Boost Immunization Strategies Using Varicella-Zoster Virus gE mRNA Vaccine and Adjuvanted Protein Subunit Vaccine Triggered Superior Cell Immune Response in Middle-Aged Mice
The heterologous prime-boost strategy has demonstrated that an mRNA-primed immunization regimen can induce a better cell-mediated immune response than a protein subunit-primed regimen in middle-aged mice. These findings provide valuable insights into the design and optimization of VZV vaccines with the potentials to broaden varicella vaccination strategies in the future.
Authors
- Lijun Bian (ORCID: https://orcid.org/0000-0002-2865-0721)
- Jingying Zhou (ORCID: https://orcid.org/0000-0002-9740-6159)
- Jinyao Cui (ORCID: https://orcid.org/0009-0000-9544-0751)
- Lili Cui (ORCID: https://orcid.org/0000-0002-0668-2837)
- Yan Chen (ORCID: https://orcid.org/0000-0003-4833-7676)
- Gaotian Li
- Liao Xing (ORCID: https://orcid.org/0009-0008-8987-4076)
- Dongdong Li (ORCID: https://orcid.org/0000-0001-6671-7475)
- Bo Sun (ORCID: https://orcid.org/0000-0003-0889-3678)
- Yong Zhang (ORCID: https://orcid.org/0000-0001-6577-5235)
- Xiaoyan Zhao (ORCID: https://orcid.org/0009-0004-2931-2865)
- Chunlai Jiang (ORCID: https://orcid.org/0000-0002-6588-3997)
- Wei Kong
Institutions
- Jilin University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/ijn.s464720
- Citations
- 11
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.25