Knockdown of KCNQ1OT1 Alleviates the Activation of NLRP3 Inflammasome Through miR-17-5p/TXNIP Axis in Retinal Müller Cells
In conclusion, it was found in this study that KCNQ1OT1 promoted the activation of NLRP3 inflammasome both <i>in vitro</i> and <i>in vivo</i>, which was mediated by miR-17-5p/TXNIP axis. KCNQ1OT1 might be an effective interference target for the prevention and treatment of DR.
Authors
- Aihua Xue
- Yuping Dou (ORCID: https://orcid.org/0009-0007-7043-1913)
- Manhui Zhu (ORCID: https://orcid.org/0000-0002-3396-0222)
- Guoping Cao
- Kai Leng
- Yü Liu (ORCID: https://orcid.org/0000-0003-2211-3535)
- Xiujuan Chen (ORCID: https://orcid.org/0000-0003-1040-9937)
- Lili Dong (ORCID: https://orcid.org/0000-0002-2222-3147)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Jiangsu Province Hospital (CN)
- He Eye Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Current Eye Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1080/02713683.2024.2378037
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23