Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis
Based on the screening of clinical samples and downstream molecular functional validation experiments, we revealed a driving role for HDACs and the HDACs-regulated CDK6/ID2 axis in Th17 cell differentiation and pathogenicity in AU, proposing a promising therapeutic strategy.
Authors
- Wenru Su (ORCID: https://orcid.org/0000-0002-0506-6362)
- Xiuxing Liu (ORCID: https://orcid.org/0000-0001-5855-6624)
- Yuhan Su (ORCID: https://orcid.org/0000-0002-8251-531X)
- Chenyang Gu (ORCID: https://orcid.org/0009-0008-6022-3341)
- Jianjie Lv (ORCID: https://orcid.org/0009-0003-4020-0883)
- Yuehan Gao
- Zhuping Xu (ORCID: https://orcid.org/0000-0002-1270-9602)
- Hui Chen (ORCID: https://orcid.org/0000-0002-8153-1326)
- Chun Zhang (ORCID: https://orcid.org/0000-0003-3565-8024)
- Jing Xiao
- Yidan Liu (ORCID: https://orcid.org/0009-0003-8444-488X)
- Nanwei Xu (ORCID: https://orcid.org/0009-0001-4902-2070)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.jare.2024.07.029
- Citations
- 11
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 4.43
Funders
- Sichuan University
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- National Postdoctoral Program for Innovative Talents
- West China Hospital, Sichuan University