Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuroprotection strategies in the neonate
BACKGROUND: Cerebral intraventricular hemorrhage (IVH) is a major cause of neurodevelopmental impairment in preterm infants.IVH is characterized by vessel rupture and a rapid accumulation of blood within the ventricles.Subsequent hemolysis leads to the release of extracellular hemoglobin (Hb) into the cerebrospinal fl uid (CSF).Hb and its metabolites initiate cytotoxic, oxidative, proinfl ammatory, and apoptotic pathways resulting in tissue damage.Scavenging of Hb, using haptoglobin (Hp), may therefore constitute a potential treatment in IVH.The aim of this study was to investigate i.) the scavenging capacity in the CSF of infants with IVH, and ii.) the clinical translatability of the preterm rabbit pup model of IVH. METHODS:Prospective observational study at a level III NICU, Skåne University Hospital, Lund, Sweden.16 extremely preterm infants with a mean (SD) gestational age at birth of 27.2 (2.7) weeks and birthweight 1042 (369) g.All infants developed either IVH grade III (N=11) or periventricular hemorrhagic infarction (N=5).All infants received a neurosurgically inserted intraventricular reservoir enabling longitudinal CSF withdrawal.Rabbit pups were delivered prematurely by cesarean section at embryonal day 29 (Term = 31-32 days of gestation).IVH was induced by intraperitoneal injection
Authors
- Marianne Simone Joerger-Messerli (ORCID: https://orcid.org/0000-0003-1491-4578)
- Aisling A. Garvey (ORCID: https://orcid.org/0000-0002-8443-3246)
- Christopher Meehan
- Alexa Craig (ORCID: https://orcid.org/0000-0002-6477-3390)
- Anya Cutler
- Donna A. Wall (ORCID: https://orcid.org/0000-0002-5442-5536)
- Karina Kempe
- Tone Nordvik
- Pelin Cengiz (ORCID: https://orcid.org/0000-0002-5682-5664)
- Kirsten Guse
- Meray Serdar (ORCID: https://orcid.org/0000-0001-7838-9413)
- Sara Cherkerzian
- Vann Chau (ORCID: https://orcid.org/0000-0001-8260-8738)
- Sarah E. Monsell (ORCID: https://orcid.org/0000-0002-2563-534X)
- Karin G. Hermans (ORCID: https://orcid.org/0000-0001-7133-7653)
- Sarah Worley
- Jon E. Levine (ORCID: https://orcid.org/0000-0003-4177-6406)
- Niklas Ortenlöf
- Lindsay Pennington (ORCID: https://orcid.org/0000-0002-4540-2586)
- Anna Basu (ORCID: https://orcid.org/0000-0002-1356-3027)
- Josephine Herz (ORCID: https://orcid.org/0000-0001-8132-7459)
- Madison Denney
- Nur Sena Çağatay
- George Maple
- Jennifer A. O’Malley (ORCID: https://orcid.org/0000-0002-4689-5941)
- Luis Monterrosa
- Nicholas Nicoletti
- Suvi Vallius
- Daniel Surbek (ORCID: https://orcid.org/0000-0001-7705-1584)
- Helena Karlsson
- Sefer Yapici
- Gunnthorunn Gunnarsdottir (ORCID: https://orcid.org/0009-0004-5938-638X)
- Sandra E. Juul (ORCID: https://orcid.org/0000-0002-6861-6229)
- Kristina Wendel (ORCID: https://orcid.org/0000-0002-9207-1927)
- Jan Miletín (ORCID: https://orcid.org/0000-0003-0489-6054)
- Andreina Schoeberlein (ORCID: https://orcid.org/0000-0002-6716-9551)
- Lina F. Chalak (ORCID: https://orcid.org/0000-0001-5496-3257)
- Sriya Roychaudhuri (ORCID: https://orcid.org/0000-0003-0291-4175)
- Feyza Çetin (ORCID: https://orcid.org/0000-0001-5714-3617)
- Fernando F. Gonzalez (ORCID: https://orcid.org/0000-0001-5893-4592)
- Sarah Edney (ORCID: https://orcid.org/0000-0002-4069-3505)
- Amita Kapoor (ORCID: https://orcid.org/0000-0001-9708-6979)
- Mandana Rizazad
- Ariel A. Sherbany
- Peter A. Ferrazzano (ORCID: https://orcid.org/0000-0002-7678-2980)
- Emily K.W. Lo (ORCID: https://orcid.org/0000-0002-0449-8083)
- Mohamed El‐Dib (ORCID: https://orcid.org/0000-0001-6979-7407)
- Amanda Kristiansson (ORCID: https://orcid.org/0000-0003-2898-7129)
- Ursula Felderhoff‐Müser (ORCID: https://orcid.org/0000-0002-7765-8893)
- Claes Ekström (ORCID: https://orcid.org/0000-0001-6635-5822)
- Claire Baldauf (ORCID: https://orcid.org/0000-0002-8888-1476)
- Courtney J. Wusthoff (ORCID: https://orcid.org/0000-0002-1882-5567)
- Thomas Gentinetta (ORCID: https://orcid.org/0009-0004-9470-9877)
- Valérie Haesler (ORCID: https://orcid.org/0000-0001-8470-0052)
- Brian Thomas Kalish (ORCID: https://orcid.org/0000-0002-3184-018X)
- Johana M. Isaza-Correa
- Ivo Bendix (ORCID: https://orcid.org/0000-0002-9751-3640)
- Magnus Gram (ORCID: https://orcid.org/0000-0002-5880-2925)
- Ellie Campbell
- Katherine M. Mackenzie (ORCID: https://orcid.org/0000-0002-1302-2298)
- Camille Bloom
- Robert C. McKinstry (ORCID: https://orcid.org/0000-0003-3578-4899)
- Kirstin Webster
- Markus Gallert
- Martin J. White (ORCID: https://orcid.org/0000-0002-1861-6757)
- Vera Tscherrig (ORCID: https://orcid.org/0000-0002-3601-5453)
- Ceyda Acun (ORCID: https://orcid.org/0000-0002-9924-1343)
- Lynne Kelly (ORCID: https://orcid.org/0000-0002-4782-1143)
- Yvonne W. Wu (ORCID: https://orcid.org/0000-0002-3641-3769)
- Raymand Pang (ORCID: https://orcid.org/0000-0002-2004-6650)
- Terrie E. Inder (ORCID: https://orcid.org/0000-0002-6012-9944)
- Amr El Shahed (ORCID: https://orcid.org/0000-0002-5898-1927)
- Judith Rankin
- Eleanor J. Molloy (ORCID: https://orcid.org/0000-0001-6798-2158)
- Aoife Branagan (ORCID: https://orcid.org/0000-0001-5220-5372)
- Helle Cecilie Viekilde Pfeiffer (ORCID: https://orcid.org/0000-0001-5136-1883)
- Tom Stiris (ORCID: https://orcid.org/0000-0002-6754-3443)
- Markus Brechmann
- Brian H. Walsh (ORCID: https://orcid.org/0000-0003-4665-6884)
- Hany Aly (ORCID: https://orcid.org/0000-0001-7395-6394)
- Ángela Hoyos (ORCID: https://orcid.org/0000-0002-5403-3268)
- Jessica L. Wisnowski (ORCID: https://orcid.org/0000-0002-4039-8362)
- Elizabeth Scharnetzki (ORCID: https://orcid.org/0000-0002-5727-0189)
- Robin W. Goy
- Marel Steinfort
- Marlen Fossan
- Amit K. Mathur (ORCID: https://orcid.org/0000-0002-9215-2014)
- Sissel Jennifer Moltu (ORCID: https://orcid.org/0000-0001-7209-071X)
- Chant Katrjian
- Valérie Verdon
- Yi Li (ORCID: https://orcid.org/0000-0001-8535-2168)
- Yujin Kim (ORCID: https://orcid.org/0000-0002-4840-9011)
- Carlos Fajardo
- Aashish Gupta
- Katie Tucker (ORCID: https://orcid.org/0009-0009-0349-3107)
- David Ley (ORCID: https://orcid.org/0000-0002-7498-6883)
- Burak Özaydın (ORCID: https://orcid.org/0000-0003-4985-160X)
- Alan Bainbridge (ORCID: https://orcid.org/0000-0001-6094-7755)
- Leah Marie Seften
- Clairette Kirezi
- Farag Shuweihdi
- Anne Breaks
- Mari Viviers
- Amanda Brosius-Lutz
- Nancy Chorne
- Luc Collo
- Irem Isik
- Rakesh Lavu
- Nadia Leake
- Marco Belzu
- Tara Lozy
- Juhi Motiani
- Ana Alvarez Pagan
- Anette Ramm-Pettersen
- Sandra Mena Perez
- Claudine Vavasseur
- Marwa Khalil (ORCID: https://orcid.org/0000-0002-4100-7853)
- Katarzyna Wiatrowska
- Abhijeet Singla
- Sreenivas Karnati
- Claudia Stanciu
- K. Walther
- Rubén Hernández
- Carolina Villegas (ORCID: https://orcid.org/0000-0002-6605-6379)
- Fransisco Torrealdea
- Tai-Wei Wu
- Rakesh Chhabra
- Katie HannonTaylor Harris
- Maggie Kucera
- Catherine Hahn
- Nicola J. Robertson
- Manuel Bernal Benitez
- Diane Wilson (ORCID: https://orcid.org/0000-0001-8350-5706)
- Ivana d’Angelo (ORCID: https://orcid.org/0000-0003-0444-0444)
Institutions
- University of Bern (CH)
- Oslo University Hospital (NO)
- Lund University (SE)
- Trinity College Dublin (IE)
- Rotunda Hospital (IE)
- University Hospital of Bern (CH)
- Children's Health Ireland at Crumlin (IE)
- Coombe Women & Infants University Hospital (IE)
- Women's Hospital (US)
- Tokyo Women's Medical University Hospital (JP)
- National Maternity Hospital (IE)
- Skåne University Hospital (SE)
- CSL (Switzerland) (CH)
Publication Details
- Journal
- Journal of Neonatal-Perinatal Medicine
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3233/npm-249002
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00