Targeting Caspases 3/6 and Cathepsins L/B May Decrease Laminopathy-Induced Apoptosis in Alzheimer’s Disease
Our findings suggest that lamins A/C, cathepsins B/L, caspase 6, and lamin B2 are associated with laminopathy as potential factors contributing to apoptosis in AD. We propose that simultaneous inhibition of caspases 6 and cathepsins L may decrease the rate of apoptosis triggered by lamin degradation. Nevertheless, further studies are required to confirm these observations due to the lack of in vivo findings.
Authors
- Mehran Ebrahimi Shah-abadi (ORCID: https://orcid.org/0000-0002-1854-6664)
- Farhad Seif (ORCID: https://orcid.org/0000-0003-1275-2157)
- Auob Rustamzadeh (ORCID: https://orcid.org/0000-0002-8246-5631)
- Abbas Tafakhori (ORCID: https://orcid.org/0000-0002-9835-0812)
- Armin Ariaei (ORCID: https://orcid.org/0000-0003-3383-9710)
- Mahdi Heydari (ORCID: https://orcid.org/0000-0001-5263-859X)
Institutions
- Iran University of Medical Sciences (IR)
- Kerman University of Medical Sciences (IR)
- Academic Center for Education, Culture and Research (IR)
- Qazvin University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3233/jad-240413
- Citations
- 7
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.64