Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology

BACKGROUND: Preterm birth is associated with significant risks for long-term impairments in brain structure and cognitive functions (1). At the microscopic level, the transient inflammatory and hypoxic-ischemic events occurring during premature birth disrupt the development of subplate neurons and pre-oligodendrocytes, both of which play a crucial role in the establishment of thalamo-cortical connections and the maturation of the claustrum (2,3). Altered thalamo-cortical connectivity and claustrum microstructure have previously been reported in preterm-born infants (4,5). This study combines findings from two investigations aiming at exploring the long-term consequences of prematurity on these subplate and pre-oligodendrocyte-dependent systems (6).&#13;\nMETHODOLOGY: Thalamo-cortical (TC) and claustro-cortical (CC) connections were reconstructed from diffusion-weighted imaging data using probabilistic tractography. Streamlines were generated between bilateral thalami or claustra and cortical regions of interest (see Figure 1A and 2A-C). Connection probability was chosen as metric of TC structural connectivity in a sample of 67 very preterm (PT) and 70 full-term (FT) born adults while CC connectivity was measured as connection density in 65 PT and 81 FT born adults of the BLS at 26 years. In both studies, cognitive performance was assessed by full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale. Additionally, a verbal comprehension subtest score was computed in the first study. Neonatal medical complications were assessed using a standardized optimality scoring system (OPTI). Differences between groups and their associations with prematurity or cognitive variables were performed via ANCOVAs and linear regressions (study 1) or Pearson correlations (study 2) respectively.&#13;\nRESULTS: Findings revealed increased connectivity between the left thalamus and left prefrontal cortex in very preterm-born adults, which was associated with both lower birth weight and a lower verbal comprehension score (Figure 1A-B). Furthermore, decreased connectivity between bilateral thalami and temporal cortices in PT born adults positively correlated with the duration of ventilation during the neonatal period (Figure 1A). Finally, lower connectivity between bilateral claustra and parieto-occipital cortices in PT born adults was associated with lower gestational age, birth weight and a higher degree of neonatal complications (Figure 3A-B). Lower left claustro-occipital connectivity was also associated with lower IQ.&#13;\n&#13;\nCONCLUSION: Together, these findings suggest that prematurity has a lasting impact on cortico-subcortical white matter connectivity, particularly in subplate/pre-oligodendrocytes-derived systems. Furthermore, these alterations are linked to the degree of prematurity and have implications for the persistence of cognitive impairments into adulthood.

Authors

Institutions

Publication Details

Journal
Journal of Neonatal-Perinatal Medicine
Published
2024-08-05
DOI
https://doi.org/10.3233/npm-249006
Primary Topic
Neonatal and fetal brain pathology
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Proceedings of the 15 th International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology

Kamini Raghuram, Neil Marlow, Ann Gallagher, Aisling A. Garvey et al.
Journal of Neonatal-Perinatal Medicine
Neonatal and fetal brain pathology
article

Proceedings of the 15 th International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology

Kamini Raghuram, Neil Marlow, Ann Gallagher, Aisling A. Garvey, Monica E. Lemmon, Bryan A. Comstock, Jehier K. Afifi, Monika Olischar, Gayane Yenokyan, Walid I. El-Naggar, Mariana Baserga, Aurore Menegaux, Madeleine Murphy, Shabina Ariff, Frances J. Northington, Renato S. Procianoy, Katharina Goeral, József Halász, Andrea F. Duncan, Betsy Ostrander, Helena Litorp, Vincent Kibet, Rita C. Silveira, Kosmas Sarafidis, Elizabeth Singh, Sara Waheddoost, Tim Hurley, Michelle Spirtos, Sujatha Kannan, Chinyere O’Connor, Jil Wendt, Thuy Mai Luu, Sadaf Kazmi, Farhana Tabassum, Lindsay Bartram, Nádia Cristina Valentini, Carolina Panceri, Yvonne Sheldon, Ashish KC, Tatiana Nuzum, Marie‐Noëlle Simard, Laurel A. Slaughter, Darrah Haffner, Breda Hayes, K.D. Colón, Deirdre Sweetman, Lara M. Leijser, Lauren Ayala, Joseph Stanek, Khorshid Mohammad, Maira Niaz, Malcolm Battin, Linda Biesty, Sandra E. Juul, Lindsay L. Richter, Ashley Bach, Dieter Wolke, Lina F. Chalak, Sriya Roychaudhuri, Susan C. Vaughan, Jean Quigley, Rachel Byrne, Lourdes I García-Tormos, J. J. Egan, Sara Moss, Alyssa Morin, Sonika Agarwal, Leticia Gely-Rojas, Nancy Poirier, Patrizia Strola, Amaris Keiser, Véronique Belval, Anne Monique Nuyt, Mohamed El‐Dib, Benita Schmitz‐Koep, B. Lukacs, Nathalie L. Maitre, Andrea Valek, Lorenzo Riboldi, Amii Kress, Alessandra Coscia, Hoda El-Shibiny, Ilias Chatziioannidis, Patricia Healy, Miklós Szabó, Patrick J. Heagerty, Anie Lapointe, Charu Venkatesan, Mathieu Dehaes, David M. Haas, Cynthia García-Coll, Ariane Léveillée, Caitlin Bernard, Deborah Cuddyer, Danielle Clifford, Emma Butler, Jaideep Kanungo, Grace Kwong, Orla Smyth, Declan Devane, Elaine Ní Bhraonáin, Chiara Peila, Xiaodi Chen, Jay Riva-Cambrin, Selphee Tang, Bohdana Marandyuk, Gabriel Côté‐Corriveau, Dennis M. Hedderich, Emily Taketa, Elizabeth A. Rogers, Elizabeth Nixon, Amit Mukerji, Yow‐Pin Lim, Anne O’Sullivan, Muthanna Samara, Robert Angert, Hajnalka Barta, Sarfaraz Momin, Mirjam Steiner, Jamie J Kirkham, Peter Bartmann, Srishti Jayakumar, Alla Kuzminsky, Vito Giordano, Karen Thomas, Jordan R. Kuiper, Lourdes García-Fragoso, Dawn Gano, Christabell Omukagah Okaronon, Francesco Raimondi, Yvonne W. Wu, Jade Robinson, Sarah Koskei, Terrie E. Inder, Amina Benlamri, Christian Sorg, Grace M. Musiime, Ann Marie LeVine, Eleanor J. Molloy, Natalie Chan, Chelo Del Rosario, Tina Steele, Frank H. Bloomfield, Antti Juhani Kukka, Leonora Hendson, Mandy Daly, Hussein Zein, M. Ryan, Brian H. Walsh, Mary Clarke, Prakesh S. Shah, Ágnes Jermendy, Nicholas H. Brown, Gwendolyn Gerner, Gina Rencken, Claus Zimmer, Carmina Erdei, Srinivas Kota, Ludovic Legros, Raul Chavez‐Valdez, Hannah C. Glass, Csaba Nádor, Ruth Getachew, Karen Walker, Roxana Stoiciu, Alina Fieraru, Stéphanie De Leeuw, Lynn Bitar, Seung Woo Lee, Martin White, Deirdre M. Murray, Yulun Liu, Catherine Bernard, Sarah Winter, John Kelleher, Anik Cloutier, Angelika Berger, Marilee C Allen, Inés García‐García, James Scott, Athanasia Anastasiou, Sara Kift, Agnes Kothencz, Kannan Natchimuthu, Juanita Negrón-Pagán, Fanni Pekli-Toth, Fiona QuirkeMarie-Josée Raboisson, Eugenia Rouka, Emeritus S. Stonestreet, Petra Sztahovits, Kostantia Tsoni, Léanne Brabant, Ioanna Giannopoulu, Anna Hamill, Noy Huta, Polaris Gonzalez, Alexandra Florinana Nemes, T. G. Wald, Adrian Ioan Toma, Margaret Moran, Angelos Baltatzidis, Vanda Pal, Rashed Chowdhury, Julia Elis, Mi-Suk Kang Dufour, Adelina Alexe, Anurudhya Karthikeyan, Elena Segal, A. Kalter, Linda O Keeffe, Marie Cornet, Danielle Sharon, Jen Keene, Eithne Lennon, Corina Mills, Kathyrn Carson, Mairead Hughes, Joaquim Miró, Tamar Steinberg, Shireen Meher, K Tari, Mélanie Gagnon, Emeritus Barbara, Colette Lynch, Ashley Duhaime, Andree Necula, Roisin Phipps, Brona Fagan
article en

Abstract

BACKGROUND: Preterm birth is associated with significant risks for long-term impairments in brain structure and cognitive functions (1). At the microscopic level, the transient inflammatory and hypoxic-ischemic events occurring during premature birth disrupt the development of subplate neurons and pre-oligodendrocytes, both of which play a crucial role in the establishment of thalamo-cortical connections and the maturation of the claustrum (2,3). Altered thalamo-cortical connectivity and claustrum microstructure have previously been reported in preterm-born infants (4,5). This study combines findings from two investigations aiming at exploring the long-term consequences of prematurity on these subplate and pre-oligodendrocyte-dependent systems (6).&#13;\nMETHODOLOGY: Thalamo-cortical (TC) and claustro-cortical (CC) connections were reconstructed from diffusion-weighted imaging data using probabilistic tractography. Streamlines were generated between bilateral thalami or claustra and cortical regions of interest (see Figure 1A and 2A-C). Connection probability was chosen as metric of TC structural connectivity in a sample of 67 very preterm (PT) and 70 full-term (FT) born adults while CC connectivity was measured as connection density in 65 PT and 81 FT born adults of the BLS at 26 years. In both studies, cognitive performance was assessed by full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale. Additionally, a verbal comprehension subtest score was computed in the first study. Neonatal medical complications were assessed using a standardized optimality scoring system (OPTI). Differences between groups and their associations with prematurity or cognitive variables were performed via ANCOVAs and linear regressions (study 1) or Pearson correlations (study 2) respectively.&#13;\nRESULTS: Findings revealed increased connectivity between the left thalamus and left prefrontal cortex in very preterm-born adults, which was associated with both lower birth weight and a lower verbal comprehension score (Figure 1A-B). Furthermore, decreased connectivity between bilateral thalami and temporal cortices in PT born adults positively correlated with the duration of ventilation during the neonatal period (Figure 1A). Finally, lower connectivity between bilateral claustra and parieto-occipital cortices in PT born adults was associated with lower gestational age, birth weight and a higher degree of neonatal complications (Figure 3A-B). Lower left claustro-occipital connectivity was also associated with lower IQ.&#13;\n&#13;\nCONCLUSION: Together, these findings suggest that prematurity has a lasting impact on cortico-subcortical white matter connectivity, particularly in subplate/pre-oligodendrocytes-derived systems. Furthermore, these alterations are linked to the degree of prematurity and have implications for the persistence of cognitive impairments into adulthood.

Journal of Neonatal-Perinatal MedicineVol. 17(3)
Uppsala University (SE), Nationwide Children's Hospital (US), Karolinska University Hospital (SE), Emory University (US), Brown University (US), Centre Hospitalier Universitaire Sainte-Justine (CA), Karolinska Institutet (SE), Gävle Hospital (SE), Children's Healthcare of Atlanta (US), Indiana University School of Medicine, Wake Forest University (US), Université de Montréal (CA), The University of Texas Southwestern Medical Center (US), University of Gothenburg (SE), University of KwaZulu-Natal (ZA)
Openalex Percentile: Top 81%
Neonatal and fetal brain pathology
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.