Anti-PF4 positivity and platelet activation after Ad26.COV2·S vaccination in Brazil
Vaccination with Ad26.COV2·S vaccine led to a very low frequency of low-titer positive anti-PF4 antibodies, elevation of D-dimer, and mild thrombocytopenia, with no associated clinically relevant increase in thromboinflammatory markers and platelet activation.
Authors
- Eduarda Grinsztejn (ORCID: https://orcid.org/0009-0002-9680-2616)
- Sandro Nazer Coutinho
- Flávia dos Santos Souza
- Stephane Vicente Rozini (ORCID: https://orcid.org/0000-0003-3856-5210)
- Beatriz Grinsztejn
- Carolina Q. Sacramento (ORCID: https://orcid.org/0000-0003-3952-7099)
- Daniela P. Mendes-de-Almeida (ORCID: https://orcid.org/0000-0002-1936-4774)
- Patrı́cia T. Bozza (ORCID: https://orcid.org/0000-0001-8349-9529)
- Brenda Hoagland (ORCID: https://orcid.org/0000-0001-8210-3748)
- AG Vizzoni (ORCID: https://orcid.org/0000-0003-0004-5084)
- Maria Helena Santos de Oliveira (ORCID: https://orcid.org/0000-0003-1180-7224)
- Kim Mattos Geraldo (ORCID: https://orcid.org/0000-0001-7788-405X)
- Joanna Bokel (ORCID: https://orcid.org/0000-0001-8420-7321)
- Remy Martins-Gonçalves (ORCID: https://orcid.org/0000-0002-1010-6162)
- Sandra Wagner Cardoso (ORCID: https://orcid.org/0000-0001-5230-0003)
- Valdilea Gonçalves Veloso (ORCID: https://orcid.org/0000-0002-6622-3165)
- Ingebourg Georg (ORCID: https://orcid.org/0000-0001-6257-1907)
Institutions
- University Hospitals of Cleveland (US)
- Fundação Oswaldo Cruz (BR)
- Western University of Health Sciences (US)
Publication Details
- Journal
- Vaccine
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1016/j.vaccine.2024.126175
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Isaac Newton Institute for Mathematical Sciences
- Fundação Oswaldo Cruz