Celastrus orbiculatus Thunb. extracts and celastrol alleviate NAFLD by preserving mitochondrial function through activating the FGF21/AMPK/PGC-1α pathway
These findings suggest that COT may enhance mitochondrial function by activating the FGF21/AMPK/PGC-1α signaling pathway to mitigate NAFLD, which indicated that COT has the potential to target mitochondria and serve as a novel therapeutic option for NAFLD.
Authors
- Shucun Qin (ORCID: https://orcid.org/0000-0002-0413-3113)
- Junli Xue (ORCID: https://orcid.org/0000-0002-0553-6993)
- Yunchao Liu (ORCID: https://orcid.org/0000-0003-1297-6396)
- Boyan Liu (ORCID: https://orcid.org/0000-0002-7646-5299)
- Xiubin Jia (ORCID: https://orcid.org/0000-0003-1584-5113)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-2873-1660)
- Xinsheng Fang
Institutions
- Shandong First Medical University (CN)
- Shandong Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fphar.2024.1444117
- Citations
- 5
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Qingdao University
- Shandong First Medical University