Dendritic cells transfected with DNA constructs encoding CCR9, IL-10, and type II collagen demonstrate induction of immunological tolerance in an arthritis model
The study presents an approach by which DCs transfected with DNA constructs encoding epitopes of type II collagen, IL-10 and CCR9 promote the development of antigen-specific tolerance, control inflammation and reduce the severity of experimental arthritis through the studied mechanisms: induction of T-reg, IL-10, TGF-β.
Authors
- A.S. Bulygin (ORCID: https://orcid.org/0000-0001-9055-6069)
- Elena K. Ivleva (ORCID: https://orcid.org/0000-0003-1194-7219)
- Julia Shevchenko (ORCID: https://orcid.org/0000-0001-8773-0599)
- V.V. Kurilin (ORCID: https://orcid.org/0000-0002-5617-0450)
- С. В. Сенников (ORCID: https://orcid.org/0000-0002-7366-7768)
- О. С. Таранов (ORCID: https://orcid.org/0000-0002-6746-8092)
- A. Z. Maksyutov (ORCID: https://orcid.org/0000-0002-4027-8299)
- Julia Philippova (ORCID: https://orcid.org/0000-0002-1158-887X)
- Marina Fisher
Institutions
- State Research Center of Virology and Biotechnology VECTOR (RU)
- Research Institute of Fundamental and Clinical Immunology (RU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fimmu.2024.1447897
- Citations
- 4
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.96