The median effective concentration of epidural ropivacaine with different doses of dexmedetomidine for motor blockade: an up-down sequential allocation study
The EC<sub>50</sub> of epidural ropivacaine required to achieve motor block was 0.677% in the NR group, 0.624% in the RD<sub>0.25</sub> group, 0.549% in the RD<sub>0.5</sub> group, 0.463% in the RD<sub>0.75</sub> group, and 0.435% in the RD<sub>1.0</sub> group. Dexmedetomidine as an adjuvant for ropivacaine dose-dependently reduce the EC<sub>50</sub> of epidural ropivacaine for motor block and shorten the onset time of epidural ropivacaine block. The optimal dose of dexmedetomidine combined with ropivacaine for epidural anesthesia was 0.5 μg/kg.
Authors
- Jixiang Wan
- WU Zhi-qiang (ORCID: https://orcid.org/0000-0003-1251-6488)
- Chao Lin (ORCID: https://orcid.org/0000-0001-7122-0068)
- Fangjun Wang (ORCID: https://orcid.org/0000-0001-5938-772X)
- Duan Feng
- Yuan Wang (ORCID: https://orcid.org/0009-0009-8509-6809)
Institutions
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fmed.2024.1413191
- Citations
- 3
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 1.72