Longitudinal transcriptomic analysis reveals persistent enrichment of iron homeostasis and erythrocyte function pathways in severe COVID-19 ARDS
These findings describe significant differences in gene regulation during patient ICU course between survivors and non-survivors of COVID-19 ARDS. We identified multiple pathways that suggest heme and red blood cell metabolism contribute to disease outcomes. This approach is generalizable to larger cohorts and supports an approach of longitudinal sampling in ARDS molecular profiling studies, which may identify novel targetable pathways of injury and resolution.
Authors
- Gabrielle Swoope
- Joseph S. Bednash (ORCID: https://orcid.org/0000-0003-3576-4388)
- Jeffrey C. Horowitz (ORCID: https://orcid.org/0000-0002-1505-2837)
- Finny Johns (ORCID: https://orcid.org/0000-0001-7143-754X)
- Rama K. Mallampalli (ORCID: https://orcid.org/0000-0002-4405-1593)
- Sarah Karow
- Joshua A. Englert (ORCID: https://orcid.org/0000-0002-1257-2239)
- Moemen Eltobgy (ORCID: https://orcid.org/0000-0002-9806-7515)
- Daniela Farkas (ORCID: https://orcid.org/0000-0002-7223-1268)
- Laura Leuenberger (ORCID: https://orcid.org/0000-0002-8991-6554)
- Sonal Pannu (ORCID: https://orcid.org/0000-0002-6745-3827)
- Kevin Ho (ORCID: https://orcid.org/0000-0002-9803-4465)
- Sarah P. Cohen
Institutions
- The Ohio State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fimmu.2024.1397629
- Citations
- 9
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Ohio State University
- National Center for Advancing Translational Sciences