Commiphora myrrha n-hexane extract suppressed breast cancer progression through induction of G0/G1 phase arrest and apoptotic cell death by inhibiting the Cyclin D1/CDK4-Rb signaling pathway
CMHE treatment resulted in the suppression of BC cell growth through the stimulation of cell cycle arrest at the G0/G1 phase and the induction of apoptotic cell death via the inhibition of the Cyclin D1/CDK4-Rb pathway, thereby enhancing the anti-BC effect of CMHE. CMHE has potential anti-BC effects, particularly in those harboring aberrant activation of Cyclin D1/CDK4-Rb signaling.
Authors
- Zhongdong Hu (ORCID: https://orcid.org/0000-0003-4849-3353)
- Jinxin Xie
- Xuejiao Wei (ORCID: https://orcid.org/0000-0003-1663-0691)
- Peng Tan (ORCID: https://orcid.org/0000-0001-8719-7472)
- Jun Li (ORCID: https://orcid.org/0000-0003-0423-3381)
- Xingxing Li (ORCID: https://orcid.org/0000-0002-8096-5106)
- Pengfei Tu (ORCID: https://orcid.org/0000-0002-3848-8174)
- Dongxiao Liu (ORCID: https://orcid.org/0000-0001-9656-8976)
- Chaochao Wang (ORCID: https://orcid.org/0009-0004-3154-6169)
- Longyan Wang (ORCID: https://orcid.org/0009-0009-3378-5194)
- Shungang Jiao
- Huiming Huang (ORCID: https://orcid.org/0000-0002-5006-813X)
- Fei Wang (ORCID: https://orcid.org/0009-0003-1472-5483)
Institutions
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fphar.2024.1425157
- Citations
- 3
- Primary Topic
- Pharmacological Effects of Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 1.34