The elasticity of silicone-stabilized liposomes has no impact on their in vivo behavior
Incorporating the silicone layer into the liposome structure did not change nanocarriers' characteristics in vivo. Further modification of the LIP-SS surface, including decoration with hydrophilic stealth polymers, should be performed to improve their pharmacokinetics and retention in tumors significantly. Activation of the immune response by LIP-SS and LIP-CAT, resulting in elevated inflammatory cytokine production, requires detailed studies to elucidate its mechanism.
Authors
- Monika Bzowska (ORCID: https://orcid.org/0000-0003-1921-0334)
- Ewa Werner (ORCID: https://orcid.org/0000-0003-4316-1683)
- Alicja Hinz (ORCID: https://orcid.org/0000-0001-8781-8427)
- Agnieszka Cierniak (ORCID: https://orcid.org/0000-0001-6537-2954)
- Krystyna Stalińska (ORCID: https://orcid.org/0000-0002-6258-6110)
- Joanna Lewandowska-Łańcucka (ORCID: https://orcid.org/0000-0002-5447-4936)
- Michał Szuwarzyński (ORCID: https://orcid.org/0000-0002-9759-4372)
- Grzegorz Dyduch (ORCID: https://orcid.org/0000-0001-6293-8350)
Institutions
- Jagiellonian University (PL)
- Andrzej Frycz Modrzewski Krakow University (PL)
- AGH University of Krakow (PL)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1186/s12951-024-02698-9
- Citations
- 1
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.17
Funders
- Narodowym Centrum Nauki
- Uniwersytet Jagielloński w Krakowie