Prenatal origin of <scp><i>NUTM1</i></scp> gene rearrangement in infant B‐cell precursor acute lymphoblastic leukaemia
Rearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B-cell precursor Acute Lymphoblastic Leukaemia (BCP-ALL). In this study we had the unique opportunity to analyze the umbilical cord blood (UCB) sample from one infant patient with NUTM1r BCP-ALL. Herein we reported for the first time that NUTM1r infant ALL arise prenatally, as both the patient-specific CUX1::NUTM1 fusion gene, as well as two IG/TR leukaemic markers were already present and detectable in the patient's UCB at birth. Our results clearly demonstrate the prenatal origin of NUTM1r infant BCP-ALL.
Authors
- Michela Bardini (ORCID: https://orcid.org/0000-0002-6942-2274)
- L Corral Abascal
- Oscar Maglia
- Stefano Rebellato (ORCID: https://orcid.org/0000-0002-8380-5255)
- Grazia Fazio (ORCID: https://orcid.org/0000-0001-7077-8422)
- Andrea Biondi (ORCID: https://orcid.org/0000-0002-6757-6173)
- Rolf Marschalek (ORCID: https://orcid.org/0000-0003-4870-3445)
- Carmelo Rizzari (ORCID: https://orcid.org/0000-0002-4828-3893)
- Claus Meyer (ORCID: https://orcid.org/0000-0003-0951-7359)
- Giovanni Cazzaniga (ORCID: https://orcid.org/0000-0003-2955-4528)
- Sonia Palamini
- Simona Sala (ORCID: https://orcid.org/0000-0001-6357-0375)
Institutions
- Goethe University Frankfurt (DE)
- Azienda Ospedaliera San Gerardo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1111/bjh.19685
- Citations
- 6
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 3.26
Funders
- Associazione Italiana per la Ricerca sul Cancro