Flexible/Regenerative Nanosensor with Automatic Sweat Collection for Cytokine Storm Biomarker Detection
The real-time monitoring of low-concentration cytokines such as TNF-α in sweat can aid clinical physicians in assessing the severity of inflammation. The challenges associated with the collection and the presence of impurities can significantly impede the detection of proteins in sweat. This issue is addressed by incorporating a nanosphere array designed for automatic sweat transportation, coupled with a reusable sensor that employs a Nafion/aptamer-modified MoS<sub>2</sub> field-effect transistor. The nanosphere array with stepwise wettability enables automatic collection of sweat and blocks impurities from contaminating the detection zone. This device enables direct detection of TNF-α proteins in undiluted sweat, within a detection range of 10 fM to 1 nM. The use of an ultrathin, ultraflexible substrate ensures stable electrical performance, even after up to 30 extreme deformations. The findings indicate that in clinical scenarios, this device could potentially provide real-time evaluation and management of patients' immune status via sweat testing.
Authors
- Zhuang Hao (ORCID: https://orcid.org/0000-0003-4776-6022)
- PingAn Hu (ORCID: https://orcid.org/0000-0003-3499-2733)
- Siyu Hou (ORCID: https://orcid.org/0000-0003-1465-3531)
- Feiran Li (ORCID: https://orcid.org/0000-0002-0046-3748)
- Yunlu Pan (ORCID: https://orcid.org/0000-0003-1836-7751)
- Cong Huang (ORCID: https://orcid.org/0000-0002-8275-9074)
- Suichu Huang (ORCID: https://orcid.org/0000-0001-5057-8095)
- Jialin Liu (ORCID: https://orcid.org/0000-0002-4836-3199)
- Shanshan Gao (ORCID: https://orcid.org/0000-0001-9373-756X)
- Weisong Yang (ORCID: https://orcid.org/0000-0003-0944-7127)
- Dongliang Li
- Xuezeng Zhao
- Weihao Feng
- Ziran Wang (ORCID: https://orcid.org/0009-0009-7693-1390)
- Hao Wang (ORCID: https://orcid.org/0009-0008-4494-6793)
Institutions
- Shandong University (CN)
- Harbin Institute of Technology (CN)
- State Key Laboratory of Robotics and Systems (CN)
- Beihang University (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1021/acsnano.4c04456
- Citations
- 26
- Primary Topic
- Advanced Sensor and Energy Harvesting Materials
- Type
- article
- Field-Weighted Citation Impact
- 4.80
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Heilongjiang Province
- Natural Science Foundation of Chongqing