Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT)
We developed and internally validated a prediction model with reasonably good predictive metrics. Clinicians, patients and carers were involved in the development process. External validation of the tool is needed followed by co-design methodology to support implementation in early intervention services.
Authors
- Gillian A. Doody (ORCID: https://orcid.org/0000-0002-3494-438X)
- Maria Antonietta Nettis (ORCID: https://orcid.org/0000-0002-5401-8391)
- Paola Dazzan (ORCID: https://orcid.org/0000-0002-8427-3617)
- Miriam Hattle (ORCID: https://orcid.org/0000-0003-1542-6277)
- Daniëlle van der Windt (ORCID: https://orcid.org/0000-0002-7248-6703)
- Robin M. Murray (ORCID: https://orcid.org/0000-0003-0829-0519)
- David Shiers (ORCID: https://orcid.org/0000-0003-2531-5837)
- Andrew J. Lawrence (ORCID: https://orcid.org/0000-0002-1420-3381)
- Richard D Riley (ORCID: https://orcid.org/0000-0001-8699-0735)
- Gabrielle Andrews
- Arsime Demjaha (ORCID: https://orcid.org/0000-0002-1870-6410)
- Saeed Farooq (ORCID: https://orcid.org/0000-0003-2088-6876)
- Olesya Ajnakina (ORCID: https://orcid.org/0000-0003-3987-1236)
- A. Milner (ORCID: https://orcid.org/0009-0001-5996-0706)
- Peter Brian Jones (ORCID: https://orcid.org/0000-0002-0387-880X)
- Tom Kingstone (ORCID: https://orcid.org/0000-0001-9179-2303)
- Marta Di Forti (ORCID: https://orcid.org/0000-0002-3218-6925)
Institutions
- University of Nottingham (GB)
- Greater Manchester Mental Health NHS Foundation Trust (GB)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- University of Cambridge (GB)
- University of Manchester (GB)
- NIHR Birmingham Liver Biomedical Research Unit (GB)
- Midlands Partnership NHS Foundation Trust (GB)
- St George's Hospital (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University College London (GB)
- Keele University (GB)
- University of Birmingham (GB)
- University of Palermo (IT)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1192/bjp.2024.101
- Citations
- 4
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- King's College London
- University College London
- Università degli Studi di Palermo
- Keele University
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Medical Research Council
- Research for Patient Benefit Programme
- Birmingham Biomedical Research Centre