Impact of childhood maltreatment on aging: a comprehensive Mendelian randomization analysis of multiple age-related biomarkers
CM is linked to accelerated biological aging, shown by shorter telomere length and increased epigenetic aging markers. CM was also associated with increased frailty, highlighting the need for early interventions to mitigate long-term effects. Further research should explore mechanisms and prevention strategies.
Authors
- Chenggang Jiang (ORCID: https://orcid.org/0000-0002-2240-831X)
- Liwei Tang
- Keyi Liu (ORCID: https://orcid.org/0000-0002-2188-0110)
- Cheng Gan (ORCID: https://orcid.org/0000-0002-2167-4966)
- Yuan H. Zhao (ORCID: https://orcid.org/0000-0002-5351-502X)
- Zheng Zhang (ORCID: https://orcid.org/0000-0002-0062-517X)
- Haitang Qiu
- Qinghua Luo (ORCID: https://orcid.org/0000-0002-0518-0990)
- Rong Han
- Hao Ren
- Qiyin Li
- Yadong Peng
- Jiangyou Yu
- Ying Liu (ORCID: https://orcid.org/0000-0002-7164-962X)
Institutions
- Chongqing City Mental Health Center (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1186/s13148-024-01720-z
- Citations
- 6
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.66
Funders
- Centre Scientifique et Technique du Bâtiment
- Medical Research Council