Effects of concurrent training and N-acetylcysteine supplementation on cardiac remodeling and oxidative stress in middle-aged spontaneously hypertensive rats
N-acetylcysteine supplementation alone reduces oxidative stress in untreated spontaneously hypertensive rats. The combination of N-acetylcysteine and concurrent exercise further decreases oxidative stress. However, the lower oxidative stress does not translate into improved cardiac remodeling and function in untreated spontaneously hypertensive rats.
Authors
- S. A. Oliveira (ORCID: https://orcid.org/0000-0002-8895-9456)
- Guilherme L. Paschoareli
- Luana Urbano Pagan (ORCID: https://orcid.org/0000-0003-1865-0207)
- Adriana Junqueira (ORCID: https://orcid.org/0000-0002-2580-6233)
- Mariana Janini Gomes (ORCID: https://orcid.org/0000-0001-5613-1585)
- E A Rodrigues (ORCID: https://orcid.org/0000-0002-8592-9374)
- Katashi Okoshi (ORCID: https://orcid.org/0000-0001-8980-8839)
- Ana Angélica Henrique Fernandes (ORCID: https://orcid.org/0000-0002-7170-182X)
- Igor C. Deprá
- Francis Lopes Pacagnelli (ORCID: https://orcid.org/0000-0003-3712-5854)
- T H D Pontes (ORCID: https://orcid.org/0000-0001-6344-5777)
- Marina Politi Okoshi (ORCID: https://orcid.org/0000-0001-7728-4505)
- A. R. R. Lima (ORCID: https://orcid.org/0000-0002-3119-5723)
- F C Damatto
Institutions
- Universidade Federal de Mato Grosso do Sul (BR)
- Universidade do Oeste Paulista (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1186/s12872-024-04075-8
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Estadual Paulista