Pharmacological mechanisms of Ma Xing Shi Gan Decoction in treating influenza virus-induced pneumonia: intestinal microbiota and pulmonary glycolysis
MXSG can alleviate glycolysis in lung tissue, suppress M1-type macrophage activation, promote M2-type macrophage activation, and mitigate inflammation in lung tissue. This therapeutic effect appears to be mediated by modulating gut microbiota and reducing endogenous LPS production in the intestines. This study demonstrates the therapeutic effects of MXSG on pneumonia and explores its potential mechanism, thus providing data support for the use of traditional Chinese medicine in the treatment of respiratory infectious diseases.
Authors
- Chen Bai (ORCID: https://orcid.org/0000-0001-8357-9027)
- Jingru Zhu
- Yang Wang (ORCID: https://orcid.org/0000-0002-6527-864X)
- Lin Jiang (ORCID: https://orcid.org/0000-0002-7114-0794)
- Su Chen (ORCID: https://orcid.org/0000-0001-7829-8108)
- Hui Liu (ORCID: https://orcid.org/0000-0001-8524-1759)
- Xiaohong Gu (ORCID: https://orcid.org/0000-0001-8361-9455)
- Qianqian Li (ORCID: https://orcid.org/0000-0002-1840-1203)
- Xueying Qin (ORCID: https://orcid.org/0000-0003-3271-8618)
- Tiegang Liu (ORCID: https://orcid.org/0000-0001-5226-441X)
Institutions
- Beijing University of Chinese Medicine (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fphar.2024.1404021
- Citations
- 12
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China