Identification of clusters of secondary metabolite biosynthetic genes in the <i>Camelina sativa</i> genome

Multidrug-resistant pathogens pose an earnest risk to human health. Therefore, new antibiotics need to be developed quickly. Most of the antibiotics we use today are derived from secondary metabolites, which are produced by plants. Genome mining tools allow us to detect biosynthetic gene clusters (BGCs) responsible for the production of secondary metabolites. Focusing on the most promising BGCs-coding antibiotics with unique pathways is currently a challenge. <i>In silico</i> approach like genome mining are used to visualise the action of these bioactive chemicals. <i>Camelina sativa</i> is a well-known medicinal plant and it would be interesting to study its secondary metabolites. In this work, we found seven bioactive compounds in this plant using the genome mining approach. Further, the clusters of genes involved in the biosynthesis of these compounds were analysed with their metabolic pathways. This work illuminates new ground on the evolution of BGCs for the nutritional improvement of <i>C. sativa.</i>

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Publication Details

Journal
Natural Product Research
Published
2024-08-05
DOI
https://doi.org/10.1080/14786419.2024.2385695
Citations
2
Primary Topic
Lipid metabolism and biosynthesis
Type
article
Field-Weighted Citation Impact
0.59
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article

Identification of clusters of secondary metabolite biosynthetic genes in the Camelina sativa genome

Aditi Nayak, Zaryab Saleha, Shagufi Zea Siddiqui
2 citations
Natural Product Research
Lipid metabolism and biosynthesis
0.59
article

Identification of clusters of secondary metabolite biosynthetic genes in the Camelina sativa genome

Aditi Nayak, Zaryab Saleha, Shagufi Zea Siddiqui
article en
2 citations

Abstract

Multidrug-resistant pathogens pose an earnest risk to human health. Therefore, new antibiotics need to be developed quickly. Most of the antibiotics we use today are derived from secondary metabolites, which are produced by plants. Genome mining tools allow us to detect biosynthetic gene clusters (BGCs) responsible for the production of secondary metabolites. Focusing on the most promising BGCs-coding antibiotics with unique pathways is currently a challenge. <i>In silico</i> approach like genome mining are used to visualise the action of these bioactive chemicals. <i>Camelina sativa</i> is a well-known medicinal plant and it would be interesting to study its secondary metabolites. In this work, we found seven bioactive compounds in this plant using the genome mining approach. Further, the clusters of genes involved in the biosynthesis of these compounds were analysed with their metabolic pathways. This work illuminates new ground on the evolution of BGCs for the nutritional improvement of <i>C. sativa.</i>

Natural Product ResearchVol. 39(23)
Life Science Institute (JP)
Zero hunger
Openalex Percentile: Top 32%
Lipid metabolism and biosynthesis
0.59
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Identification of clusters of secondary metabolite biosynthetic genes in the <i>Camelina sativa</i> genome — Aditi Nayak, Zaryab Saleha, et al. · Natural Product Research (2024) | TGRS Research Map | TGRS