Organic solvent-free benznidazole nanosuspension as an approach to a novel pediatric formulation for Chagas disease

<b>Aim:</b> Benznidazole (BNZ), a class-II drug, is the primary treatment for Chagas disease, but its low aqueous solubility presents challenges in formulation and efficacy. Nanosuspensions (NS) could potentially address these issues.<b>Methods:</b> BNZ-NS were prepared using a simple, organic solvents-free nano-milling approach. Physicochemical characterizations were conducted on both NS and lyophilized solid-state BNZ-nanocrystals (NC).<b>Results:</b> BNZ-NS exhibited particle size <500 nm, an acceptable polydispersity index (0.23), high Z-potential, and physical stability for at least 90 days. BNZ-NC showed tenfold higher solubility than pure BNZ. Dissolution assays revealed rapid BNZ-NS dissolution. BNZ-NC demonstrated biocompatibility on an eukaryotic cell and enhanced BNZ efficacy against trypomastigotes of <i>Trypanosoma cruzi</i>.<b>Conclusion:</b> BNZ-NS offers a promising alternative, overcoming limitations associated with BNZ for optimized pharmacotherapy.

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Publication Details

Journal
Therapeutic Delivery
Published
2024-08-05
DOI
https://doi.org/10.1080/20415990.2024.2380244
Citations
5
Primary Topic
Trypanosoma species research and implications
Type
article
Field-Weighted Citation Impact
1.93

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article

Organic solvent-free benznidazole nanosuspension as an approach to a novel pediatric formulation for Chagas disease

Constanza Marín, Belkys Angélica Maletto, Cinthia Carolina Stempin, Mónica Cristina García et al.
5 citations
Therapeutic Delivery
Trypanosoma species research and implications
1.93
article

Organic solvent-free benznidazole nanosuspension as an approach to a novel pediatric formulation for Chagas disease

Constanza Marín, Belkys Angélica Maletto, Cinthia Carolina Stempin, Mónica Cristina García, Lucía López-Vidal, Alvaro F. Jimenez‐Kairuz, Santiago Daniel Palma, Juan Pablo Real, María Sol Magi
article en
5 citations

Abstract

<b>Aim:</b> Benznidazole (BNZ), a class-II drug, is the primary treatment for Chagas disease, but its low aqueous solubility presents challenges in formulation and efficacy. Nanosuspensions (NS) could potentially address these issues.<b>Methods:</b> BNZ-NS were prepared using a simple, organic solvents-free nano-milling approach. Physicochemical characterizations were conducted on both NS and lyophilized solid-state BNZ-nanocrystals (NC).<b>Results:</b> BNZ-NS exhibited particle size <500 nm, an acceptable polydispersity index (0.23), high Z-potential, and physical stability for at least 90 days. BNZ-NC showed tenfold higher solubility than pure BNZ. Dissolution assays revealed rapid BNZ-NS dissolution. BNZ-NC demonstrated biocompatibility on an eukaryotic cell and enhanced BNZ efficacy against trypomastigotes of <i>Trypanosoma cruzi</i>.<b>Conclusion:</b> BNZ-NS offers a promising alternative, overcoming limitations associated with BNZ for optimized pharmacotherapy.

Therapeutic DeliveryVol. 15(9)
Consejo Nacional de Investigaciones Científicas y Técnicas (AR), Universidad Nacional de Córdoba (AR)
Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas, Ministerio de Salud de la Nación, Secretaria de Ciencia y Tecnología - Universidad Nacional de Córdoba, Agencia Nacional de Promoción Científica y Tecnológica
Zero hunger
Openalex Percentile: Top 13%
Trypanosoma species research and implications
1.93
DOIOpen Access PDFOpenAlex
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