Dietary therapy of murine primary biliary cholangitis induces hepatocellular steatosis: A cautionary tale
Our data suggest that administration of HAMSP induces both regulatory and effector T cells. Furthermore, HAMSP administration resulted in hepatocellular steatosis. Given the interest in dietary modulation of autoimmunity and because propionate is widely used as a food preservative, these data have significant implications. This study also provides new insights into the immunological and pathological effects of chronic propionate exposure.
Authors
- Luke S. Heuer (ORCID: https://orcid.org/0009-0008-5539-2968)
- Patrick S.C. Leung (ORCID: https://orcid.org/0000-0001-5862-4316)
- Koichi Tsuneyama (ORCID: https://orcid.org/0000-0002-0670-9868)
- William M. Ridgway (ORCID: https://orcid.org/0000-0002-9569-3932)
- Merrill Eric Gershwin (ORCID: https://orcid.org/0000-0001-5245-2680)
- Manuel Rojas (ORCID: https://orcid.org/0000-0002-8604-4658)
- Weici Zhang (ORCID: https://orcid.org/0000-0002-3193-6851)
- Charles R. Mackay (ORCID: https://orcid.org/0000-0002-6338-7340)
- Howard A. Young (ORCID: https://orcid.org/0000-0002-3118-5111)
- Aftab A. Ansari (ORCID: https://orcid.org/0000-0003-4607-7268)
- Taha Al Tekreeti
- Harleen Dhillon
Institutions
- Australian Regenerative Medicine Institute (AU)
- Frederick National Laboratory for Cancer Research (US)
- Center for Cancer Research (US)
- Monash University (AU)
- University of California, Davis (US)
- Universidad del Rosario (CO)
- Tokushima University (JP)
Publication Details
- Journal
- Liver International
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1111/liv.16060
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Cancer Institute