Anticandidal activity of <i>Croton heliotropiifolius</i> Kunth essential oil is enhanced by N-acetylcysteine and itraconazole

<b>Aim:</b> Evaluate the anticandidal effect of <i>Croton heliotropiifolius</i> Kunth essential oil and its interaction with azoles and N-acetylcysteine (NAC) against planktonic cells and biofilms.<b>Materials & methods:</b> Broth microdilution and checkerboard methods were used to evaluate the individual and combined activity with fluconazole and itraconazole (ITRA). The antibiofilm effect of the oil was assessed in 96-well plates alone and combined with ITRA and NAC, and cytotoxicity determined by MTT.<b>Results:</b> The oil inhibited all <i>Candida</i> species growth. The activity was enhanced when associated with ITRA and NAC for planktonic cells and biofilms in formation. The effective concentrations were lower than the toxic ones to V79 cells.<b>Conclusion:</b> <i>C. heliotropiifolius</i> Kunth essential oil is an anticandidal alternative, and can be associated with ITRA and NAC.

Authors

Institutions

Publication Details

Journal
Future Microbiology
Published
2024-08-05
DOI
https://doi.org/10.1080/17460913.2024.2380601
Citations
1
Primary Topic
Essential Oils and Antimicrobial Activity
Type
article
Field-Weighted Citation Impact
0.35
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Anticandidal activity of Croton heliotropiifolius Kunth essential oil is enhanced by N-acetylcysteine and itraconazole

Islay Lima Magalhães, Cecília Rocha da Silva, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral et al.
1 citations
Future Microbiology
Essential Oils and Antimicrobial Activity
0.35
article

Anticandidal activity of Croton heliotropiifolius Kunth essential oil is enhanced by N-acetylcysteine and itraconazole

Islay Lima Magalhães, Cecília Rocha da Silva, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Lisandra Juvêncio da Silva, Bruno Coêlho Cavalcanti, Lívia Gurgel do Amaral Valente Sá, Amanda Dias Barbosa, Hélio Vitoriano Nobre Júnior, Cláudio Costa dos Santos, João Batista de Andrade Neto, Manoel Odorico de Moraes
article en
1 citations

Abstract

<b>Aim:</b> Evaluate the anticandidal effect of <i>Croton heliotropiifolius</i> Kunth essential oil and its interaction with azoles and N-acetylcysteine (NAC) against planktonic cells and biofilms.<b>Materials & methods:</b> Broth microdilution and checkerboard methods were used to evaluate the individual and combined activity with fluconazole and itraconazole (ITRA). The antibiofilm effect of the oil was assessed in 96-well plates alone and combined with ITRA and NAC, and cytotoxicity determined by MTT.<b>Results:</b> The oil inhibited all <i>Candida</i> species growth. The activity was enhanced when associated with ITRA and NAC for planktonic cells and biofilms in formation. The effective concentrations were lower than the toxic ones to V79 cells.<b>Conclusion:</b> <i>C. heliotropiifolius</i> Kunth essential oil is an anticandidal alternative, and can be associated with ITRA and NAC.

Future MicrobiologyVol. 19(15)
Universidade Federal do Ceará (BR), Unichristus (BR), Universidade Federal Rural do Semi-Árido (BR)
Zero hunger
Openalex Percentile: Top 37%
Essential Oils and Antimicrobial Activity
0.35
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.