Irreversible electroporation of localised prostate cancer downregulates immune suppression and induces systemic anti‐tumour T‐cell activation – <scp>IRE</scp> ‐ <scp>IMMUNO</scp> study
Irreversible electroporation induces a PCa-specific systemic immune response in patients with localised PCa, aiding conversion of the tumour microenvironment into a more immune permissive state. Therapeutic efficacy might be further enhanced by combination with CTLA-4 checkpoint inhibition, potentially opening up a new synergistic treatment paradigm for high-risk localised or (oligo)metastatic disease.
Authors
- Shikha Agrawal (ORCID: https://orcid.org/0000-0003-3214-786X)
- Bart Geboers (ORCID: https://orcid.org/0000-0002-8137-9299)
- Phillip D. Stricker (ORCID: https://orcid.org/0000-0002-0934-0656)
- Matthijs J. V. Scheltema (ORCID: https://orcid.org/0000-0002-9098-9574)
- Martijn R. Meijerink (ORCID: https://orcid.org/0000-0002-1500-7294)
- Paul Doan (ORCID: https://orcid.org/0000-0003-4946-7982)
- William Gondoputro (ORCID: https://orcid.org/0000-0002-7076-4781)
- Susan J. Clark (ORCID: https://orcid.org/0000-0001-5925-5030)
- Jayne Matthews
- Joyce Bakker
- Alexandar Blazevski
- James Thompson (ORCID: https://orcid.org/0000-0002-5115-9930)
- Tanja D. de Gruijl (ORCID: https://orcid.org/0000-0003-1464-8978)
- Athos Katelaris (ORCID: https://orcid.org/0000-0002-8637-3793)
- Florentine E. F. Timmer (ORCID: https://orcid.org/0000-0001-6388-9001)
- Jason J. Jung (ORCID: https://orcid.org/0000-0003-0050-7445)
- Xanthe Cerutti
- Anne‐Maree Haynes
- Tim Robertson
Institutions
- Prostate Cancer Foundation of Australia (AU)
- Garvan Institute of Medical Research (AU)
- St. Antonius Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- The Kinghorn Cancer Centre (AU)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- British Journal of Urology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1111/bju.16496
- Citations
- 11
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- Paul Ramsay Foundation
- Cancer Center Amsterdam