Slow rewarming after hypothermia does not ameliorate white matter injury after hypoxia-ischemia in near-term fetal sheep
Persistent white matter injury is a major contributor to long-term disability after neonatal encephalopathy despite treatment with therapeutic hypothermia. The optimal rate to rewarm infants after therapeutic hypothermia is unclear; current protocols were developed on a precautionary basis. We now show that slow rewarming at 0.5 °C/h did not improve histological white matter injury compared with rapid spontaneous rewarming after a clinically established duration of hypothermia in near-term fetal sheep.
Authors
- Joanne O. Davidson (ORCID: https://orcid.org/0000-0002-6781-4258)
- Guido Wassink (ORCID: https://orcid.org/0000-0002-6053-2864)
- Anthony Davies
- Laura Bennet (ORCID: https://orcid.org/0000-0002-4336-7596)
- Alice McDouall (ORCID: https://orcid.org/0000-0002-5062-9849)
- Alistair Jan Gunn (ORCID: https://orcid.org/0000-0003-0656-7035)
- Kelly Q. Zhou (ORCID: https://orcid.org/0000-0002-8220-6840)
- Timothy L. M. Jones
Institutions
- University of Auckland (NZ)
- Auckland University of Technology (NZ)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1038/s41390-024-03332-y
- Citations
- 4
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.44
Funders
- Health Research Council of New Zealand