Intravenous low-dose cyclophosphamide pulses followed by rituximab for ocular mucous membrane pemphigoid

Cyclophosphamide (CyP) is the immunosuppressive agent of choice in ocular mucous membrane pemphigoid (MMP). However, guidelines do not specify the regimen modality of CyP treatment. We introduce our practical management protocol for ocular MMP using fixed low-dose intravenous (IV) pulses of CyP followed by IV rituximab, accompanied by case studies of two elderly patients who achieved complete and enduring remissions without adverse effects.

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Publication Details

Journal
Clinical and Experimental Dermatology
Published
2024-08-05
DOI
https://doi.org/10.1093/ced/llae316
Primary Topic
Autoimmune Bullous Skin Diseases
Type
article
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article

Intravenous low-dose cyclophosphamide pulses followed by rituximab for ocular mucous membrane pemphigoid

Myriam Viedma‐Martínez, D. Jiménez‐Gallo, M. Linares‐Barrios, J.F. Millán‐Cayetano et al.
Clinical and Experimental Dermatology
Autoimmune Bullous Skin Diseases
article

Intravenous low-dose cyclophosphamide pulses followed by rituximab for ocular mucous membrane pemphigoid

Myriam Viedma‐Martínez, D. Jiménez‐Gallo, M. Linares‐Barrios, J.F. Millán‐Cayetano, Antonio José Durán‐Romero, Ricardo Patricio Roman-Cheuque, Alejandro Claudio-Oliva
article en

Abstract

Cyclophosphamide (CyP) is the immunosuppressive agent of choice in ocular mucous membrane pemphigoid (MMP). However, guidelines do not specify the regimen modality of CyP treatment. We introduce our practical management protocol for ocular MMP using fixed low-dose intravenous (IV) pulses of CyP followed by IV rituximab, accompanied by case studies of two elderly patients who achieved complete and enduring remissions without adverse effects.

Clinical and Experimental DermatologyVol. 50(1)
Hospital Universitario Puerta del Mar (ES)
Good health and well-being
Openalex Percentile: Top 80%
Autoimmune Bullous Skin Diseases
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