Epidemiology of allelic gene variants of hereditary thrombophilic condition in the population of the Arkhangelsk region

Single-nucleatide substitutions in genes encoding proteins of the hemostasis system and platelet receptors are one of the causes of hereditary predisposition to hypercoagulation and increased thrombosis. The aim is to assess the prevalence of individual allelic variants of hemostasis genes in the population of the Arkhangelsk region. Materials and methods: The study included two groups of participants from the Arkhangelsk region: patients of the Regional Center for Antithrombotic Therapy (RCATT) (n = 2354) and healthy volunteers (n = 195). The molecular genetic study of the polymorphism of the genes of the hemostasis system was carried out by PCR. The results of the study: According to the results of the study, there was no statistically significant difference in the distribution of unfavorable allelic variants of \hemostasis genes between the two groups of participants. Probably, in order to realize the hereditary tendency to increased thrombosis, it is necessary to combine the polymorphism of the studied genes with other