Lycium barbarum glycopeptide promotes neuroprotection in ET-1 mediated retinal ganglion cell degeneration
LbGP demonstrated neuroprotective effects in a mouse model of ET-1 induced RGC degeneration, with treatment applied either as a pretreatment, immediate or delayed posttreatment. LbGP treatment promoted a better restoration of retinal blood flow, and protected the RNFL, RGC density and retinal functions. This study showed the translational potential of LB as complementary treatment for glaucoma management.
Authors
- Henry Ho‐lung Chan (ORCID: https://orcid.org/0000-0002-8516-4711)
- Yamunadevi Lakshmanan
- Kwok‐Fai So (ORCID: https://orcid.org/0000-0003-4039-4246)
- Francisca Siu Yin Wong
Institutions
- Hong Kong Polytechnic University (HK)
- Jinan University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1186/s12967-024-05526-8
- Citations
- 6
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.23
Funders
- Research Grants Council, University Grants Committee
- Hong Kong Polytechnic University