Plasma extracellular vesicle long RNA profiling identifies a predictive signature for immunochemotherapy efficacy in lung squamous cell carcinoma
This study highlighted the potential of plasma exLR profiles in predicting LUSC treatment efficacy. Intriguingly, lower p-Signature scores were associated with increased abundance of activated CD4+ and CD8+ T cells, indicating a more robust immune environment. These findings suggest that the p-Signature could serve as a valuable tool in guiding personalized and effective therapeutic strategies for LUSC.
Authors
- Wenyue Yang (ORCID: https://orcid.org/0000-0001-9357-4334)
- Xianghua Wu
- Zhihuang Hu
- Qiaojuan Li
- Si Sun (ORCID: https://orcid.org/0000-0002-8424-5763)
- Zhen Wang (ORCID: https://orcid.org/0000-0001-9289-4889)
- Jialei Wang (ORCID: https://orcid.org/0000-0001-9977-2219)
- Xinmin Zhao
- Hui Yu (ORCID: https://orcid.org/0000-0002-4489-841X)
- Huijie Wang
- Xin Zhang (ORCID: https://orcid.org/0000-0001-6036-2685)
- Jiatao Liao
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-05
- DOI
- https://doi.org/10.3389/fimmu.2024.1421604
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Shanghai Anti-Cancer Association
- Shanghai Municipal Health Commission
- Science and Technology Commission of Shanghai Municipality