Syndecan‐4 inhibition attenuates cartilage degeneration in temporomandibular joint osteoarthritis
SDC4 inhibition significantly ameliorates condylar cartilage degeneration, which was mediated, at least partly, through P38 and ERK1/2 signalling. Inhibition of SDC4 may be of great value for the treatment of TMJOA.
Authors
- Yuanjun Ma (ORCID: https://orcid.org/0009-0005-4806-0584)
- Ying Zhan (ORCID: https://orcid.org/0000-0003-0693-1941)
- Feng He
- Xiaohua Chen
- Fan Wu (ORCID: https://orcid.org/0000-0002-0091-4262)
- Jia Yu (ORCID: https://orcid.org/0000-0003-1849-6449)
- Zhuo Wang (ORCID: https://orcid.org/0000-0002-2858-7646)
- Qin Han (ORCID: https://orcid.org/0000-0002-7317-0823)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-6871-307X)
- Mian Zhang (ORCID: https://orcid.org/0000-0003-2464-361X)
- Hongyun Zhang (ORCID: https://orcid.org/0000-0002-8955-1460)
- Lei Lü
- Shibin Yu (ORCID: https://orcid.org/0000-0001-8428-1249)
Institutions
- Chinese PLA General Hospital (CN)
- Xian Mental Health Center (CN)
- General Hospital of Central Theater Command
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Oral Rehabilitation
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1111/joor.13829
- Citations
- 4
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shaanxi Province
- Key Research and Development Projects of Shaanxi Province