Metformin enhances endogenous neural stem cells proliferation, neuronal differentiation, and inhibits ferroptosis through activating AMPK pathway after spinal cord injury
Metformin, driven by canonical AMPK-dependent regulation, promotes proliferation and neuronal differentiation of endogenous NSCs while inhibiting ferroptosis, thereby facilitating recovery of locomotor function following SCI. Our study further elucidates the protective mechanism of metformin in SCI, providing new mechanistic insights for its candidacy as a therapeutic agent for SCI.
Authors
- Liyue Wang
- Guangzhi Ning (ORCID: https://orcid.org/0000-0002-1635-9902)
- Shibo Zhu
- Hongpeng Ma
- Hao Zhong (ORCID: https://orcid.org/0000-0003-0537-8582)
- Cong Xing (ORCID: https://orcid.org/0000-0002-4363-3196)
- Mi Zhou (ORCID: https://orcid.org/0009-0003-1009-3896)
- Song Liu (ORCID: https://orcid.org/0000-0001-6166-4669)
- Qiang Wu (ORCID: https://orcid.org/0000-0002-7512-0109)
Institutions
- Tianjin University (CN)
- Tianjin Medical University General Hospital (CN)
- China International Science and Technology Cooperation (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1186/s12967-024-05436-9
- Citations
- 22
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City