In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia
Cardiac dysfunction during sepsis is not primarily due to elevated endogenous or exogenous catecholamines nor due to decreased microvascular perfusion-induced ischemia. However, epinephrine itself has potentially harmful long-lasting ischemic effects during sepsis including impaired cardiac microvascular perfusion that persists after stopping the infusion.
Authors
- Michael A. Solomon (ORCID: https://orcid.org/0000-0001-7400-6614)
- Parizad Torabi‐Parizi (ORCID: https://orcid.org/0000-0002-7446-1702)
- Robert L. Danner (ORCID: https://orcid.org/0000-0001-5715-3823)
- Charles Natanson (ORCID: https://orcid.org/0000-0001-9712-2538)
- Harvey G. Klein (ORCID: https://orcid.org/0000-0002-4625-8467)
- Verity J. Ford (ORCID: https://orcid.org/0000-0002-1364-8522)
- Steven B. Solomon (ORCID: https://orcid.org/0009-0009-9279-607X)
- Marcus Y. Chen (ORCID: https://orcid.org/0000-0003-0743-9369)
- Juan J.L. Lertora (ORCID: https://orcid.org/0009-0003-2068-8316)
- Willard N. Applefeld (ORCID: https://orcid.org/0000-0002-1326-5839)
- Jeffrey Wang (ORCID: https://orcid.org/0000-0002-6900-8268)
- Jing Feng (ORCID: https://orcid.org/0009-0002-5755-7478)
- Junfeng Sun
Institutions
- Pennington Biomedical Research Center (US)
- Louisiana State University (US)
- National Institutes of Health (US)
- Emory University (US)
- National Heart, Lung, and Blood Institute (US)
- Duke Medical Center (US)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1161/jaha.123.034027
- Citations
- 3
- Primary Topic
- Takotsubo Cardiomyopathy and Associated Phenomena
- Type
- article
- Field-Weighted Citation Impact
- 1.21