Cardiac Magnetic Resonance Studies in a Large Animal Model That Simulates the Cardiac Abnormalities of Human Septic Shock

The cardiac dysfunction of sepsis is associated with wall edema. In nonsurvivors, at 0 to 24 hours, sepsis induces a more severe diastolic dysfunction, further decreasing chamber size. The loss of left ventricular mass with wall thinning in septic survivors may, in part, explain the EDV increases from 24 to 48 hours because of a potentially reparative process removing damaged wall tissue. Septic cardiomyopathy is most consistent with a nonocclusive microvascular injury resulting in edema causing reversible systolic and diastolic dysfunction with more severe diastolic dysfunction being associated with a decreased EDV and death.

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Publication Details

Journal
Journal of the American Heart Association
Published
2024-08-05
DOI
https://doi.org/10.1161/jaha.123.034026
Citations
6
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
2.32

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article

Cardiac Magnetic Resonance Studies in a Large Animal Model That Simulates the Cardiac Abnormalities of Human Septic Shock

Vandana Sachdev, Michael A. Solomon, Zu‐Xi Yu, Cynthia L. Sheffield et al.
6 citations
Journal of the American Heart Association
Sepsis Diagnosis and Treatment
2.32
article

Cardiac Magnetic Resonance Studies in a Large Animal Model That Simulates the Cardiac Abnormalities of Human Septic Shock

Vandana Sachdev, Michael A. Solomon, Zu‐Xi Yu, Cynthia L. Sheffield, Parizad Torabi‐Parizi, Stanislav Sidenko, Robert L. Danner, Charles Natanson, Harvey G. Klein, Verity J. Ford, Steven B. Solomon, Marcus Y. Chen, Willard N. Applefeld, Jeffrey Wang, Jing Feng, Junfeng Sun
article en
6 citations

Abstract

The cardiac dysfunction of sepsis is associated with wall edema. In nonsurvivors, at 0 to 24 hours, sepsis induces a more severe diastolic dysfunction, further decreasing chamber size. The loss of left ventricular mass with wall thinning in septic survivors may, in part, explain the EDV increases from 24 to 48 hours because of a potentially reparative process removing damaged wall tissue. Septic cardiomyopathy is most consistent with a nonocclusive microvascular injury resulting in edema causing reversible systolic and diastolic dysfunction with more severe diastolic dysfunction being associated with a decreased EDV and death.

Journal of the American Heart AssociationVol. 13(15)
National Institutes of Health (US), Emory University (US), United States National Library of Medicine (US), National Heart, Lung, and Blood Institute (US), Duke Medical Center (US), National Institutes of Health Clinical Center (US)
National Institutes of Health, NIH Clinical Center
Good health and well-being
Openalex Percentile: Top 11%
Sepsis Diagnosis and Treatment
2.32
DOIOpen Access PDFOpenAlex
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