<i>p</i>-TsOH-Mediated Intramolecular C2-Arylation on NH-Indoles: Access of 5,10-Dihydroindeno[1,2-<i>b</i>]indoles
5,10-Dihydroindeno[1,2-<i>b</i>]indole has served as an important starting precursor for BARAC-fluor reagent in medicinal chemistry. Herein, an unprecedented <i>p</i>-TsOH assisted intramolecular C2-arylation of NH-indoles via C(sp<sup>2</sup>)-CN/C(sp<sup>2</sup>)-H coupling, offering a series of 5,10-dihydroindeno[1,2-<i>b</i>]indoles with moderate to good yields, has been showcased under redox-neutral conditions. Furthermore, successful scalability and synthetic applications highlight the practical nature of the method.
Authors
- Anurag Verma (ORCID: https://orcid.org/0000-0002-5063-9107)
- Nayan Ghosh (ORCID: https://orcid.org/0000-0002-6626-045X)
- Ruchir Kant
Institutions
- Central Drug Research Institute (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-05
- DOI
- https://doi.org/10.1021/acs.orglett.4c02051
- Citations
- 4
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- University Grants Commission
- Science and Engineering Research Board